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Literature summary extracted from

  • Takashima, A.
    Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in adult brain (2009), J. Pharmacol. Sci., 109, 174-178.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.26 lithium
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.26 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.26 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.26 ATP + protein tau
-
 Mus musculus ADP + protein tau phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.26 glycogen synthase kinase-3beta
-
 Mus musculus
2.7.11.26 GSK-3beta
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.26 ATP
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.11.26 malfunction GSK-3beta heterozygote mice, which express GSK-3beta at 50% wild type levels, have impaired memory reconsolidation but normal memory consolidation Mus musculus
2.7.11.26 physiological function GSK-3beta activation is required for memory reconsolidation in the adult brain Mus musculus