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Literature summary extracted from

  • Ma, L.; Uchida, H.; Nagai, J.; Inoue, M.; Aoki, J.; Ueda, H.
    Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain (2010), J. Pharmacol. Exp. Ther., 333, 540-546.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.4 drug development targeted inhibition of PLA2- and autotaxin-mediated lysophosphatidic acid synthesis may be a potential strategy for the prevention of nerve injury-induced neuropathic pain Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.39 expressed in B-103 cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 arachidonyl trifluoromethyl ketone AACOCF3, both de novo lysophosphatidic acid production and neuropathic pain-like behaviors are substantially abolished by intrathecal injection of arachidonyl trifluoromethyl ketone, a mixed inhibitor of cPLA2 and iPLA2, at 1 h after injury Mus musculus
3.1.1.4 bromoenol lactone both de novo lysophosphatidic acid production and neuropathic pain-like behaviors are substantially abolished by intrathecal injection of bromoenol lactone, an iPLA2 inhibitor, at 1 h after injury Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.39 lysophosphatidylcholine + H2O Mus musculus
-
 lysophosphatidic acid + choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Mus musculus
-
 male C57BL/6J mice
-
3.1.4.39 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 spinal cord
-
 Mus musculus
-
3.1.4.39 spinal cord
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 arachidonyl thio-PC + H2O
-
 Mus musculus arachidonic acid + (7R)-4-hydroxy-N,N,N-trimethyl-7-sulfanyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide
-
 ?
3.1.4.39 lysophosphatidylcholine + H2O
-
 Mus musculus lysophosphatidic acid + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 calcium-independent phospholipase A2
-
 Mus musculus
3.1.1.4 cPLA2
-
 Mus musculus
3.1.1.4 cytosolic phospholipase A2
-
 Mus musculus
3.1.1.4 iPLA2
-
 Mus musculus
3.1.4.39 ATX
-
 Mus musculus
3.1.4.39 autotaxin
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.1.4.39 Mus musculus the concentration and enzyme activity of ATX are not affected by nerve injury additional information

General Information

EC Number General Information Comment Organism
3.1.1.4 physiological function PLA2- and autotaxin-mediated de novo lysophosphatidic acid production in the early phase is involved in nerve injury-induced neuropathic pain Mus musculus