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Literature summary extracted from

  • Yahata, N.; Yuasa, S.; Araki, T.
    Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration (2009), J. Neurosci., 29, 6276-6284.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.7.1 medicine the mitochondrial localization of NMNAT activity plays an important role in NMNAT expression-mediated axonal protection Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.1 transgenic mice overexpressing NMNAT1 and the mutant WldS(W258A) are generated Mus musculus
2.7.7.1 transgenic mice overexpressing NMNAT3 are generated Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.1 additional information naturally occuring mutant mice, wldS, showing delayed Wallerian degeneration phenotype, suggest that axonal degeneration is an active process, the wldS mutation comprises an 85 kb tandem triplicon, which causes overexpression of the chimeric WldS protein composed of the N-terminal 70 aa of Ufd2a/Ube4b, an ubiquitin-chain assembly factor, fused to the complete sequence of NMNAT1 Mus musculus
2.7.7.1 WldS(W258A) the chimeric WldS protein is composed of the N-terminal 70 aa of Ufd2a/Ube4b, an ubiquitin-chain assembly factor, fused to the complete sequence of NMNAT1, the W258A mutation disrupts the NAD-synthesizing activity Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.1 mitochondrial matrix
-
 Mus musculus 5759
-
2.7.7.1 mitochondrion
-
 Mus musculus 5739
-
2.7.7.1 nucleus
-
 Mus musculus 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Mus musculus Q99JR6 NMNAT3
-
2.7.7.1 Mus musculus Q9EPA7 NMNAT1
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.1 prepared from cerebrum for activity assays Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.1 neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Mus musculus diphosphate + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.1 nicotinamide mononucleotide adenylyltransferase nicotinate nucleotide can also act as acceptor, see also EC 2.7.7.18 nicotinate-nucleotide adenylyltransferase Mus musculus
2.7.7.1 NMNAT
-
 Mus musculus
2.7.7.1 NMNAT1 nuclear isoform Mus musculus
2.7.7.1 NMNAT3 mitochondrial isoform Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.1 37
-
 activity assay Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.1 7.4
-
 activity assay Mus musculus

General Information

EC Number General Information Comment Organism
2.7.7.1 physiological function NMNAT1 is an enzyme in the NAD biosynthetic pathway that generates NAD in the nucleus Mus musculus