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Literature summary extracted from

  • Amori, L.; Guidetti, P.; Pellicciari, R.; Kajii, Y.; Schwarcz, R.
    On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo (2009), J. Neurochem., 109, 316-325.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.9 (1S,2S)-2-(3,4-dichlorobenzoyl)-cyclopropane-1-carboxylic acid KMO inhibitor UPF 648, totally blocks KMO at 0.1 and 0.01 mM and is still highly active at 0.001 mM (81% inhibition). It reduces 3-hydroxykynurenine synthesis by 64% without affecting kynurenic acid formation. In neuron-depleted striata, UPF 648 decreases both 3-hydroxykynurenine and quinolinic acid production by 77% and 66%, respectively and also raises kynurenic acid synthesis by 27%. 0.1 mM UPF 648 blocks KMO in both lesioned and contralateral striatum, but does not interfere with KAT activity in either tissue Rattus norvegicus
1.14.13.9 (S)-9-(4-aminopiperazine-1-yl)-8-fluoro-3-methyl-6-oxo-2,3,5,6-tetrahydro-4H-1-oxa-3a-azaphenalene-5-carboxylic acid does not affect KMO activity significantly, 1 mM inhibits by 17% Rattus norvegicus
2.6.1.7 (S)-9-(4-aminopiperazine-1-yl)-8-fluoro-3-methyl-6-oxo-2,3,5,6-tetrahydro-4H-1-oxa-3a-azaphenalene-5-carboxylic acid BFF 122, KAT II activity is totally blocked at 0.01 mM, 43% inhibition of KAT II at 0.001 mM, 26% inhibition of KAT I at 1 mM Rattus norvegicus
2.6.1.7 additional information KAT is not inhibited by UPF 648 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.9 Rattus norvegicus
-
-
-
2.6.1.7 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.7 partial purification Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.9 brain lesioned and contralateral striatum Rattus norvegicus
-
2.6.1.7 brain
-
 Rattus norvegicus
-
2.6.1.7 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.9 L-kynurenine + NADPH + O2
-
 Rattus norvegicus 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?
2.6.1.7 L-kynurenine + 2-oxobutyrate
-
 Rattus norvegicus kynurenic acid + 2-aminobutanoate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.9 KMO
-
 Rattus norvegicus
2.6.1.7 KAT I
-
 Rattus norvegicus
2.6.1.7 KAT II
-
 Rattus norvegicus
2.6.1.7 kynurenine aminotransferase I
-
 Rattus norvegicus
2.6.1.7 kynurenine aminotransferase II
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.7 pyridoxal 5'-phosphate
-
 Rattus norvegicus