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Literature summary extracted from

  • Zeng, B.Y.; Balfour, R.H.; Jackson, M.J.; Rose, S.; Jenner, P.
    Expression of catechol-O-methyltransferase in the brain and periphery of normal and MPTP-treated common marmosets (2010), J. Neural Transm., 117, 45-51.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.6 additional information COMT activity appears unaffected by loss of the dopaminergic nigrostriatal pathway and levodopa treatment Callithrix jacchus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.6 membrane MB-COMT Callithrix jacchus 16020
-
2.1.1.6 soluble S-COMT Callithrix jacchus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Callithrix jacchus
-
 common marmoset
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.6 brain cortex
-
 Callithrix jacchus
-
2.1.1.6 liver
-
 Callithrix jacchus
-
2.1.1.6 striatum
-
 Callithrix jacchus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.6 L-Dopa + S-adenosyl-L-methionine
-
 Callithrix jacchus S-adenosyl-L-homocysteine + 3-O-methyldopa
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.6 COMT
-
 Callithrix jacchus
2.1.1.6 MB-COMT membrane-bound COMT Callithrix jacchus
2.1.1.6 S-COMT soluble COMT Callithrix jacchus