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Literature summary extracted from

  • Beauclerk, A.A.; Cundliffe, E.
    Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides (1987), J. Mol. Biol., 193, 661-671.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA Micromonospora echinospora the enzyme gives resistance to kanamycin plus gentamicin by converting residue C-1405 to 7-methylguanosine S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.180 S-adenosyl-L-methionine + adenine1408 in 16S rRNA Streptomyces tenjimariensis resistance to kanamycin plus apramycin results from conversion of residue adenine1408 to 1-methyladenine S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.179 Micromonospora echinospora
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-
-
2.1.1.180 Streptomyces tenjimariensis
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA
-
 Micromonospora echinospora S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA the enzyme gives resistance to kanamycin plus gentamicin by converting residue C-1405 to 7-methylguanosine Micromonospora echinospora S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.180 S-adenosyl-L-methionine + adenine1408 in 16S rRNA resistance to kanamycin plus apramycin results from conversion of residue adenine1408 to 1-methyladenine Streptomyces tenjimariensis S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
-
 ?
2.1.1.180 S-adenosyl-L-methionine + adenine1408 in 16S rRNA precise location of methylation site Streptomyces tenjimariensis S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.180 kanamycin-apramycin resistance methylase
-
 Streptomyces tenjimariensis

General Information

EC Number General Information Comment Organism
2.1.1.179 physiological function the enzyme gives resistance to kanamycin plus gentamicin by converting guanine1405 to 7-methylguanine Micromonospora echinospora
2.1.1.180 physiological function resistance to kanamycin plus apramycin results from conversion of residue adenine1408 to 1-methyladenine Streptomyces tenjimariensis