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Literature summary extracted from

  • Ochiai, T.; Saito, Y.; Saitoh, T.; Dewan, M.Z.; Shioya, A.; Kobayashi, M.; Kawachi, H.; Muto, S.; Itai, A.; Uota, S.; Eishi, Y.; Yamamoto, N.; Tanaka, S.; Arii, S.; Yamaoka, S.
    Inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells (2008), J. Med. Dent. Sci., 55, 49-59.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.11.10 medicine inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells Mus musculus
2.7.11.10 medicine inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.10 IMD-0354 specific IKKbeta inhibition Homo sapiens
2.7.11.10 IMD-0354 specific IKKbeta inhibition Mus musculus
2.7.11.10 RNAi specific IKKbeta inhibition Homo sapiens
2.7.11.10 RNAi specific IKKbeta inhibition Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein] Mus musculus
-
 ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 ATP + [IkappaB protein] Homo sapiens
-
 ADP + [IkappaB phosphoprotein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Homo sapiens
-
-
-
2.7.11.10 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.10 PANC-1 cell
-
 Homo sapiens
-
2.7.11.10 pancreas
-
 Mus musculus
-
2.7.11.10 PK-8 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein]
-
 Mus musculus ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 ATP + [IkappaB protein]
-
 Homo sapiens ADP + [IkappaB phosphoprotein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 IkappaB kinase beta
-
 Mus musculus
2.7.11.10 IkappaB kinase beta
-
 Homo sapiens
2.7.11.10 IKKbeta
-
 Mus musculus
2.7.11.10 IKKbeta
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.10 ATP
-
 Mus musculus
2.7.11.10 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.11.10 physiological function IkappaB kinase is a central kinase for nuclear factor-kappaB activation Mus musculus
2.7.11.10 physiological function IkappaB kinase is a central kinase for nuclear factor-kappaB activation Homo sapiens