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Literature summary extracted from

  • Harayama, T.; Shindou, H.; Shimizu, T.
    Biosynthesis of phosphatidylcholine by human lysophosphatidylcholine acyltransferase 1 (2009), J. Lipid Res., 50, 1824-1831.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.23 FLAG-tegged version expressed in CHO-K1 cell, expressed in HeLa cell Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.23 C211F C211 is essential for activity Homo sapiens
2.3.1.23 C211R C211 is essential for activity Homo sapiens
2.3.1.23 C211S C211 is essential for activity Homo sapiens
2.3.1.23 N213A putative N-glycosylation site Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.23 N-ethylmaleimide 15 min preincubation on ice with 40 mM: activity completely abolished Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.23 Homo sapiens Q8NF37
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.23 A-549 cell
-
 Homo sapiens
-
2.3.1.23 HEK-293 cell
-
 Homo sapiens
-
2.3.1.23 HeLa cell
-
 Homo sapiens
-
2.3.1.23 leukocyte
-
 Homo sapiens
-
2.3.1.23 lung
-
 Homo sapiens
-
2.3.1.23 placenta
-
 Homo sapiens
-
2.3.1.23 spleen
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.23 1-palmitoyl-2-lysophosphatidylcholine + palmitoyl-CoA activity observed only in the presence of phosphatidylcholine (1 mg/ml) Homo sapiens 1,2-dipalmitoylphosphatidylcholine + CoA
-
 ?
2.3.1.23 1-palmitoyl-2-lysophosphatidylglycerol + palmitoyl-CoA activity observed only in the presence of phosphatidylcholine (1 mg/ml) Homo sapiens 1,2-dipalmitoylphosphatidylglycerol + CoA
-
 ?
2.3.1.23 lyso-platelet-activating factor + acetyl-CoA activity observed only in the presence of phosphatidylcholine (1 mg/ml) Homo sapiens platelet-activating factor + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.23 LPCAT1
-
 Homo sapiens
2.3.1.23 lysophosphatidylcholine acyltransferase 1
-
 Homo sapiens