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Literature summary extracted from
- Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor (2009), J. Ind. Microbiol. Biotechnol., 36, 1473-1482.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 6.4.1.3 | into plasmid pSET152 derivative containing an ermE* promoter, yielding pYJ269, expressed in Streptomyces clavuligerus CKD1119 | Streptomyces coelicolor |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.4.99.2 | Streptomyces clavuligerus | - |
- |
- |
| 5.4.99.2 | Streptomyces clavuligerus CKD1119 | - |
- |
- |
| 6.4.1.3 | Streptomyces coelicolor | - |
A3(2) | - |
| 6.4.1.3 | Streptomyces coelicolor A3(2) | - |
A3(2) | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.2 | (R)-2-methylmalonyl-CoA | - |
Streptomyces clavuligerus | succinyl-CoA | - |
? |  |
| 5.4.99.2 | (R)-2-methylmalonyl-CoA | - |
Streptomyces clavuligerus CKD1119 | succinyl-CoA | - |
? | |
| 6.4.1.3 | propionyl-CoA + CO2 | - |
Streptomyces coelicolor | (2S)-methylmalonyl-CoA | - |
? | |
| 6.4.1.3 | propionyl-CoA + CO2 | - |
Streptomyces coelicolor A3(2) | (2S)-methylmalonyl-CoA | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.4.99.2 | MCM | - |
Streptomyces clavuligerus |
| 6.4.1.3 | PCC | - |
Streptomyces coelicolor |
| 6.4.1.3 | Propionyl-CoA carboxylase | - |
Streptomyces coelicolor |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.4.99.2 | adenosylcobalamin | - |
Streptomyces clavuligerus | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 5.4.99.2 | physiological function | the MCM pathway plays a key role in increasing the methylmalonyl-CoA pool for FK506 (tacrolimus) biosynthesis in Streptomyces clavuligerus CKD1119 | Streptomyces clavuligerus |
| 7.2.4.3 | physiological function | the propionyl-CoA carboxylase pathway does not increase the production of FK506, a polyketide macrolide with immunosuppressant activity, in Streptomyces clavuligerus CKD1119 | Streptomyces coelicolor |
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