Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Shord, S.; Patel, S.
    Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines (2009), J. Exp. Clin. Cancer Res., 28, 76.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.74 paclitaxel paclitaxel increases dCK (10% to 50%) activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 NCI-H460 cell
-
 Homo sapiens
-
2.7.1.74 NCI-H520 cell
-
 Homo sapiens
-
2.7.1.74 non-small cell lung cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + 2',2'-difluoro-2'-deoxycytidine i.e. gemcitabine Homo sapiens ADP + 2',2'-difluoro-2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.74 ATP
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.1.74 Homo sapiens paclitaxel significantly decreases dCK mRNA and protein levels in H460 and H520 cells down