BRENDA - Enzyme Database show

Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines

Shord, S.; Patel, S.; J. Exp. Clin. Cancer Res. 28, 76 (2009)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.74
paclitaxel
paclitaxel increases dCK (10% to 50%) activity
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
NCI-H460 cell
-
Homo sapiens
-
2.7.1.74
NCI-H520 cell
-
Homo sapiens
-
2.7.1.74
non-small cell lung cancer cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2',2'-difluoro-2'-deoxycytidine
i.e. gemcitabine
704900
Homo sapiens
ADP + 2',2'-difluoro-2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + 2'-deoxycytidine
-
704900
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.74
paclitaxel
paclitaxel increases dCK (10% to 50%) activity
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
NCI-H460 cell
-
Homo sapiens
-
2.7.1.74
NCI-H520 cell
-
Homo sapiens
-
2.7.1.74
non-small cell lung cancer cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2',2'-difluoro-2'-deoxycytidine
i.e. gemcitabine
704900
Homo sapiens
ADP + 2',2'-difluoro-2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + 2'-deoxycytidine
-
704900
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
2.7.1.74
Homo sapiens
paclitaxel significantly decreases dCK mRNA and protein levels in H460 and H520 cells
down
Expression (protein specific)
EC Number
Organism
Commentary
Expression
2.7.1.74
Homo sapiens
paclitaxel significantly decreases dCK mRNA and protein levels in H460 and H520 cells
down