Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Russell, P.; Williams, A.; Marquez, K.; Hua, T.; Ehya, F.; Hardamon, C.; Tallman, T.; Valdez, P.
    Effect of ammonium, sodium, and potassium ions on rabbit muscle phosphofructokinase-1 and adenylate kinase activities (2009), J. Enzyme Inhib. Med. Chem., 24, 930-936.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.11 K+ about 30% residual activity of 30 nM PFK-1 in the presence of 0.2 M K+ Bos taurus
2.7.1.11 K+ about 30% residual activity of 30 nM PFK-1 in the presence of 0.2 M K+ Oryctolagus cuniculus
2.7.1.11 Lactate dehydrogenase lactate dehydrogenase suspended in 3.2 M ammonium sulfate inhibits 30 nM PFK-1 resulting in a more than 50% inhibition of activity Bos taurus
2.7.1.11 Lactate dehydrogenase lactate dehydrogenase suspended in 3.2 M ammonium sulfate inhibits 30 nM PFK-1 resulting in a more than 50% inhibition of activity Oryctolagus cuniculus
2.7.1.11 Na+ about 70% residual activity of 30 nM PFK-1 in the presence of 0.2 M Na+ Bos taurus
2.7.1.11 Na+ about 70% residual activity of 30 nM PFK-1 in the presence of 0.2 M Na+ Oryctolagus cuniculus
2.7.1.11 NH4+ about 40% residual activity of 30 nM PFK-1 in the presence of 0.2 M NH4+ Bos taurus
2.7.1.11 NH4+ about 40% residual activity of 30 nM PFK-1 in the presence of 0.2 M NH4+ Oryctolagus cuniculus
2.7.4.3 ascorbate
-
 Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.11 additional information Na+ has little or no effect at 140 nM PFK-1 Bos taurus
2.7.1.11 additional information Na+ has little or no effect at 140 nM PFK-1 Oryctolagus cuniculus
2.7.4.3 K+ 30 nM of AK loses about 75% of its activity but regains activity losses owing to the presence of monovalent salts like K+ Oryctolagus cuniculus
2.7.4.3 Na+ 30 nM of AK loses about 75% of its activity but regains activity losses owing to the presence of monovalent salts like Na+ Oryctolagus cuniculus
2.7.4.3 NH4+ 30 nM of AK loses about 75% of its activity but regains activity losses owing to the presence of monovalent salts like NH4+ Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.11 Bos taurus
-
-
-
2.7.1.11 Oryctolagus cuniculus
-
-
-
2.7.4.3 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.11 muscle
-
 Bos taurus
-
2.7.1.11 muscle
-
 Oryctolagus cuniculus
-
2.7.4.3 muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.11 ATP + D-fructose 6-phosphate
-
 Bos taurus ADP + D-fructose 1,6-bisphosphate
-
 ?
2.7.1.11 ATP + D-fructose 6-phosphate
-
 Oryctolagus cuniculus ADP + D-fructose 1,6-bisphosphate
-
 ?
2.7.4.3 ATP + AMP
-
 Oryctolagus cuniculus ADP + ADP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.11 PFK-1
-
 Bos taurus
2.7.1.11 PFK-1
-
 Oryctolagus cuniculus
2.7.1.11 phosphofructokinase-1
-
 Bos taurus
2.7.1.11 phosphofructokinase-1
-
 Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.11 ATP
-
 Bos taurus
2.7.1.11 ATP
-
 Oryctolagus cuniculus