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Literature summary extracted from

  • Taibi, G.; Di Gaudio, F.; Nicotra, C.M.
    Xanthine dehydrogenase processes retinol to retinoic acid in human mammary epithelial cells (2008), J. Enzyme Inhib. Med. Chem., 23, 317-327.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.17.1.4 cellular retinol binding protein CRBP and CRABP, strictly dependent on Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.1.4 oxypurinol complete inhibition at 0.004 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.1.4 additional information
-
 additional information kinetics in presence and absence of cellular retinol binding proteins, apo-CRBP and apo-CRABP, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.1.4 cytosol immunohistochemic determination Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.4 additional information Homo sapiens xanthine dehydrogenase is the native form of xanthine oxidase, EC 1.17.3.2, conversion causes a loss of the NAD+ binding activity and of the retinol oxidation activity, the conversion with conformational changes is reversible, except for alteration due to proteolytic cleavage ?
-
 ?
1.17.1.4 xanthine + NAD+ + H2O Homo sapiens
-
 urate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.1.4 native enzyme partially from mammary gland epithelial cells by gel filtration Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
1.17.1.4 xanthine + NAD+ + H2O = urate + NADH + H+ reaction mechanism with substrate all-trans-retinol, overview Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.1.4 epithelium mammary epithelial cell line Homo sapiens
-
1.17.1.4 mammary gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.4 additional information xanthine dehydrogenase is the native form of xanthine oxidase, EC 1.17.3.2, conversion causes a loss of the NAD+ binding activity and of the retinol oxidation activity, the conversion with conformational changes is reversible, except for alteration due to proteolytic cleavage Homo sapiens ?
-
 ?
1.17.1.4 xanthine + NAD+ + H2O
-
 Homo sapiens urate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.1.4 Retinol dehydrogenase
-
 Homo sapiens
1.17.1.4 XDH
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.1.4 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.1.4 7.4
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.4 NAD+
-
 Homo sapiens