Literature summary extracted from

Ruckhaeberle, E.; Karn, T.; Hanker, L.; Gaetje, R.; Metzler, D.; Holtrich, U.; Kaufmann, M.; Rody, A.
Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer (2009), J. Cancer Res. Clin. Oncol., 135, 81-90.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.1.80	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.1.80	UDP-glucose + ceramide	-	Homo sapiens	UDP + glucosylceramide	-	ir

Synonyms

EC Number	Synonyms	Comment	Organism
2.4.1.80	GCS	-	Homo sapiens
2.4.1.80	glucosylceramide synthase	-	Homo sapiens
2.4.1.80	Ugcg	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
2.4.1.80	malfunction	In an analysis of microarray data of in a large cohort of 1681 breast tumors, there was a benefit for disease free survival for patients with tumors displaying low levels of GCS expression, especially in tumors with a positive estrogen receptor (ER) status.	Homo sapiens

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Release 2023.1 (January 2023)