Literature summary extracted from

Seyrantepe, V.; Iannello, A.; Liang, F.; Kanshin, E.; Jayanth, P.; Samarani, S.; Szewczuk, M.R.; Ahmad, A.; Pshezhetsky, A.V.
Regulation of phagocytosis in macrophages by neuraminidase 1 (2010), J. Biol. Chem., 285, 206-215.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.2.1.18	cathepsin A	-	Mus musculus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.2.1.18	cell surface	-	Mus musculus	9986	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.2.1.18	Mus musculus	O35657	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.2.1.18	kidney	-	Mus musculus	-
3.2.1.18	macrophage	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.2.1.18	2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O	-	Mus musculus	4-methylumbelliferone + N-acetylneuraminic acid	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.2.1.18	NEU1	-	Mus musculus
3.2.1.18	neuraminidase 1	-	Mus musculus

General Information

EC Number	General Information	Comment	Organism
3.2.1.18	malfunction	the absence of Neu1 results in the increased sialylation of the cell surface proteins, probably affecting multiple receptors for phagocytosis. Macrophages from the Neu1-deficient mice show increased sialylation and impaired phosphorylation of FcgammaRas well as markedly reduced phosphorylation of Syk kinase in response to treatment with immunoglobulin G-opsonized beads	Mus musculus
3.2.1.18	physiological function	treatment of the cells with purified mouse Neu1 reduces surface sialylation and restores phagocytosis. Cell surface Neu1 activates the phagocytosis in macrophages and dendritic cells through desialylation of surface receptors, thus, contributing to their functional integrity	Mus musculus

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Release 2023.1 (January 2023)