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Literature summary extracted from

  • Gurgul-Convey, E.; Lenzen, S.
    Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells (2010), J. Biol. Chem., 285, 11121-11128.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
5.3.99.4 medicine prostacyclin synthase overexpression apparently protects insulin-producing cells against cytokine toxicity via suppression of endoplasmic reticulum and mitochondrial stress-mediated cell death pathways Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.99.4 into the pcDNA3.1 vector for transfection of insulin-producing RINm5F cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.4 U51605
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.99.4 57000
-
 determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.4 Prostaglandin H2 Homo sapiens
-
 Prostaglandin I2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 Prostaglandin H2
-
 Homo sapiens Prostaglandin I2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.4 prostacyclin synthase
-
 Homo sapiens