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Literature summary extracted from

  • Jansen, S.; Andries, M.; Derua, R.; Waelkens, E.; Bollen, M.
    Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin (2009), J. Biol. Chem., 284, 14296-14302.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.4.39 medicine inhibitors of autotaxin can be used as a therapy for the treatment of cancer Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.39 expressed in HEK-293 cells Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.39 C194A the mutant shows a specific activity similar to the wild type enzyme Rattus norvegicus
3.1.4.39 C366A the mutant shows a specific activity similar to the wild type enzyme Rattus norvegicus
3.1.4.39 C413A weakly active Rattus norvegicus
3.1.4.39 C468A the mutant shows a specific activity similar to the wild type enzyme Rattus norvegicus
3.1.4.39 C513A the mutant shows a specific activity similar to the wild type enzyme Rattus norvegicus
3.1.4.39 C651A the mutant shows a specific activity similar to the wild type enzyme Rattus norvegicus
3.1.4.39 C666A the mutant shows a specific activity similar to the wild type enzyme Rattus norvegicus
3.1.4.39 C774A the mutant shows a specific activity similar to the wild type enzyme Rattus norvegicus
3.1.4.39 C784A the mutant shows a specific activity similar to the wild type enzyme Rattus norvegicus
3.1.4.39 C805A weakly active Rattus norvegicus
3.1.4.39 additional information NPP2-(1-594) lacking the nuclease-like domain does not exhibit any lysophospholipase-D or nucleotide phosphodiesterase activities Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 4-nitrophenyl-TMP + H2O
-
 Rattus norvegicus 4-nitrophenol + TMP
-
 ?
3.1.4.39 lysophosphatidylcholine + H2O
-
 Rattus norvegicus lysophosphatidic acid + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.39 autotaxin
-
 Rattus norvegicus
3.1.4.39 lysophospholipase-D
-
 Rattus norvegicus
3.1.4.39 NPP2
-
 Rattus norvegicus
3.1.4.39 nucleotide pyrophosphatase/phosphodiesterase 2
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.1.4.39 physiological function autotoxin promotes metastasis and tumor growth Rattus norvegicus