Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Asamitsu, K.; Yamaguchi, T.; Nakata, K.; Hibi, Y.; Victoriano, A.F.; Imai, K.; Onozaki, K.; Kitade, Y.; Okamoto, T.
    Inhibition of human immunodeficiency virus type 1 replication by blocking IkappaB kinase with noraristeromycin (2008), J. Biochem., 144, 581-589.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.11.10 medicine IKK is thought to be a focal target of drug development Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.10 Flag-IKKalpha and Flag-IKKbeta vectors for transfection of HEK293 cells are used Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.10 noraristeromycin NAM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.10 cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein] Homo sapiens
-
 ADP + [IkappaB phosphoprotein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.10 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 ATP + NF-kappaB p65 subunit IKKalpha and IKKbeta phosphorylate NF-kappaB p65 subunit at Ser536 Homo sapiens ADP + phosphorylated NF-kappaB p65 subunit
-
 ?
2.7.11.10 ATP + [IkappaB protein]
-
 Homo sapiens ADP + [IkappaB phosphoprotein]
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.10 oligomer IKK is a large molecular weight complex consisting of at least two catalytic subunits, IKKalpha, IKKbeta, and the associated regulatory subunit IKKgamma, NEMO Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 IkappaB kinase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.10 ATP
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.10 0.00037
-
 IKKalpha Homo sapiens noraristeromycin
2.7.11.10 0.00064
-
 inhibited endogenous IKK activity following TNF-alpha stimulation Homo sapiens noraristeromycin