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Literature summary extracted from

  • Lengsfeld, C.; Schoenert, S.; Dippel, R.; Boos, W.
    Glucose- and glucokinase-controlled mal gene expression in Escherichia coli (2009), J. Bacteriol., 191, 701-712.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.1 expressed in Escherichia coli Thermus thermophilus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.1 0.16
-
 ATP
-
 Thermus thermophilus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Thermus thermophilus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.1 ATP + D-glucose
-
 Thermus thermophilus ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 ATP + D-mannose
-
 Thermus thermophilus ADP + D-mannose 6-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.1 dimer or tetramer at ambient temperature the enzyme represents an equilibrium of dimeric and tetrameric forms Thermus thermophilus

Synonyms

EC Number Synonyms Comment Organism
2.7.1.1 glk
-
 Thermus thermophilus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.1 70
-
-
 Thermus thermophilus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.7.1.1 37
-
 the enzyme is still active at 37°C Thermus thermophilus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.1 ATP
-
 Thermus thermophilus

General Information

EC Number General Information Comment Organism
2.7.1.1 physiological function overexpressed glucokinase due to its structural similarity with Mlc, the repressor of malT, binds to the glucose transporter (PtsG), releasing Mlc and thus increasing malT repression Thermus thermophilus