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Literature summary extracted from

  • Kojic, M.; Topisirovic, L.; Vasiljevic, B.
    Translational autoregulation of the sgm gene from Micromonospora zionensis (1996), J. Bacteriol., 178, 5493-5498.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA Micromonospora zionensis the enzyme encodes an enzyme that modifies 16S rRNA and thereby confers resistance to 4,6-disubstituted deoxystreptamine aminoglycosides S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.179 Micromonospora zionensis Q7M0R2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA
-
 Micromonospora zionensis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA the enzyme encodes an enzyme that modifies 16S rRNA and thereby confers resistance to 4,6-disubstituted deoxystreptamine aminoglycosides Micromonospora zionensis S-adenosyl-L-homocysteine + 7-methylguanine1405 in 16S rRNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.179 sgm
-
 Micromonospora zionensis
2.1.1.179 sisomicin-gentamicin resistance methylase
-
 Micromonospora zionensis

General Information

EC Number General Information Comment Organism
2.1.1.179 physiological function encodes an enzyme that modifies 16S rRNA and thereby confers resistance to 4,6-disubstituted deoxystreptamine aminoglycosides. The expression of the sgm gene is regulated by the translational autorepression Micromonospora zionensis