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Literature summary extracted from
- Tryptophanase-catalyzed L-tryptophan synthesis from D-serine in the presence of diammonium hydrogen phosphate (2009), Int. J. Mol. Sci., 10, 2578-2590.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.99.1 | diammonium hydrogen phosphate | diammonium hydrogen phosphate serves as an activator on tryptophan synthesis from D-serine, maximum activity at 20% saturation concentration | Escherichia coli |  |
| 4.1.99.1 | additional information | NaCl, NH4H2PO4, NH4NO3, NH4Cl, (BH4)2CO3, K2HPO4, and Na2HPO4 have no effect on enzyme activity | Escherichia coli |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.99.1 | diammonium hydrogen phosphate | diammonium hydrogen phosphate serves as an inhibitor of tryptophanase when L-serine is substrate, the activity decreases with increasing diammonium hydrogen phosphate | Escherichia coli | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.99.1 | Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.99.1 | D-serine + indole | the presence of 20% saturation concentration of diammonium hydrogen phosphate is required for this reaction | Escherichia coli | L-tryptophan + H2O | - |
? | |
| 4.1.99.1 | L-serine + indole | - |
Escherichia coli | L-tryptophan + H2O | - |
? | |
| 4.1.99.1 | L-Trp + H2O | - |
Escherichia coli | indole + pyruvate + NH4+ | - |
? | |
| 4.1.99.1 | additional information | tryptophanase displays no activity on D-tryptophan under usual conditions. However, it becomes active toward D-tryptophan degradation in highly concentrated diammonium hydrogen phosphate solutions | Escherichia coli | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.99.1 | Tpase | - |
Escherichia coli |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.99.1 | pyridoxal 5'-phosphate | - |
Escherichia coli | |
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Release 2023.1 (January 2023)
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