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Literature summary extracted from

  • Tang, H.; Park, S.; Sun, S.C.; Trumbly, R.; Ren, G.; Tsung, E.; Yeung, K.C.
    RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex (2010), FEBS Lett., 584, 662-668.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.10 TAK1 critical direct upsteam activating kinase of IKK Homo sapiens
2.7.11.10 TRAF6 upstream activator of IKK kinase complex Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein] Homo sapiens
-
 ADP + [IkappaB phosphoprotein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.10 293-IL-1RI cell
-
 Homo sapiens
-
2.7.11.10 A-549 cell
-
 Homo sapiens
-
2.7.11.10 DU-145 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein]
-
 Homo sapiens ADP + [IkappaB phosphoprotein]
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.10 heterotrimer IkappaB kinase, IKK, consists of two catalytic subunits, IKKalpha and IKKbeta, and a regulatory subunit called NEMO or IKKgamma Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 IkappaB kinase
-
 Homo sapiens
2.7.11.10 IKK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.10 ATP
-
 Homo sapiens