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Literature summary extracted from

  • Hai, X.; Adams, E.; Hoogmartens, J.; Van Schepdael, A.
    Enantioselective in-line and off-line CE methods for the kinetic study on cimetidine and its chiral metabolites with reference to flavin-containing monooxygenase genetic isoforms (2009), Electrophoresis, 30, 1248-1257.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.8 additional information
-
 additional information Michaelis-Menten kinetics Homo sapiens
1.14.13.8 4.31
-
 cimetidine pH 8.3, S-oxygenation with (+)-enantiomer formation by isozyme FMO1 Homo sapiens
1.14.13.8 4.56
-
 cimetidine pH 8.3, S-oxygenation with (-)-enantiomer formation by isozyme FMO1 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.8 endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.8 Homo sapiens
-
 FMO multigene family
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.8 kidney FMO1 is expressed primarily in the kidney and the fetal liver Homo sapiens
-
1.14.13.8 liver FMO1 is expressed primarily in the kidney and the fetal liver Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.8 cimetidine + NADPH + H+ + O2 S-oxygenation of cimetidine, i.e. CIM, a histamine H2-receptor antagonist of therapeutic utility in the treatment of peptic ulcer disease and gastric hypersecretory syndromes. Development of in-line screening and an off-line chiral CE method for determination of the stereoselectivity of flavin-containing monooxygenase isoforms FMO1, FMO3, and FMO5 using chiral specific selectors, overview Homo sapiens cimetidine S-oxide + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.8 FMO
-
 Homo sapiens
1.14.13.8 FMO1
-
 Homo sapiens
1.14.13.8 FMO3
-
 Homo sapiens
1.14.13.8 FMO5
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.13.8 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.13.8 8.3
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.8 NADPH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.13.8 metabolism FMOs are involved in Phase I metabolism catalyzing the NADPH-dependent oxygenation of drugs, xenobiotics and endogenous compounds containing a soft nucleophilic heteroatom, typically nitrogen or sulfur, but in some cases also selenium or phosphorous Homo sapiens