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Literature summary extracted from

  • Wanwimolruk, S.; Wong, K.; Wanwimolruk, P.
    Variable inhibitory effect of different brands of commercial herbal supplements on human cytochrome P-450 CYP3A4 (2009), Drug Metabol. Drug Interact., 24, 17-35.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.55 grape seed extract some brands cause minor activation of CYP3A4 Homo sapiens

Application

EC Number Application Comment Organism
1.14.14.55 medicine green tea extract use may cause significant interactions with drugs metabolized by CYP3A4. Effect on CYP3A4 varies among different brands of green tea extract, possibly due to variations in their content of the herbal product's active ingredients Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.55 grape seed extract inhibition ranges from 6.4% to 26.8% dependent on the product Homo sapiens
1.14.14.55 green tea extract most pronounced inhibition of CYP3A4, which ranges from 5.6% to 89.9% dependent on the product Homo sapiens
1.14.14.55 additional information ginseng products have little to no effect on the activity of CYP3A4 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.55 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.55 Homo sapiens P08684
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.55 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.55 quinine + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.55 CYP3A4
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.55 NADPH
-
 Homo sapiens