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Literature summary extracted from

  • Ng, A.; Uribe, R.A.; Yieh, L.; Nuckels, R.; Gross, J.M.
    Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development (2009), Development, 136, 2601-2611.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
6.3.4.13 additional information zygotic gart and paic mutants have pigmentation defects in which xanthophore and iridophore pigmentation is almost completely absent, and melanin-derived pigmentation is significantly decreased, even though pigment cells are present in normal amounts and distributions. Zygotic gart and paics mutants are also microphthalmic, resulting from defects in cell cycle exit of proliferative retinoblasts within the developing eye, severe phenotypes, overview Danio rerio

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.13 additional information Danio rerio the enzyme is trifunctional exhibiting phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, and phosphoribosylaminoimidazole synthetase activities, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.6 Danio rerio
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 bifunctional enzyme with phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase activities
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6.3.4.13 Danio rerio
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 gene gart
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.13 embryo
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 Danio rerio
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6.3.4.13 eye
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 Danio rerio
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.13 additional information the enzyme is trifunctional exhibiting phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, and phosphoribosylaminoimidazole synthetase activities, overview Danio rerio ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.4.13 Phosphoribosylglycinamide synthetase
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 Danio rerio

General Information

EC Number General Information Comment Organism
6.3.2.6 physiological function Zygotic paics mutants have pigmentation defects in which xanthophore and iridophore pigmentation is almost completely absent, and melanin-derived pigmentation is significantly decreased, even though pigment cells are present in normal amounts and distributions. Zygotic paics mutants are also microphthalmic, resulting from defects in cell cycle exit of proliferative retinoblasts within the developing eye. Maternal-zygotic and maternal-effect mutants demonstrate a crucial requirement for maternally derived paics, these mutants show more severe developmental defects than their zygotic counterparts Danio rerio
6.3.4.13 malfunction gart and paics mutants have pigmentation defects and microphthalmia Danio rerio
6.3.4.13 metabolism the trifunctional enzyme catalyzes steps 2, 3, and 5 of inosine monophosphate synthesis, followed by paics encoded phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase, a bifunctional enzyme that catalyzes steps 6 and 7 of this process. Crucial requirement for maternally derived gart and paics. De novo purine synthesis pathway, overview Danio rerio
6.3.4.13 physiological function gart and paics function are required for eye growth. IMP feeds into an ATP pathway required for retinoblast proliferation and a GTP pathway required for pigmentation Danio rerio