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Literature summary extracted from

  • Nikolaou, N.; Watanabe-Asaka, T.; Gerety, S.; Distel, M.; Koester, R.W.; Wilkinson, D.G.
    Lunatic fringe promotes the lateral inhibition of neurogenesis (2009), Development, 136, 2523-2533.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.222 Danio rerio
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.222 epithelial cell Lfng is required cell autonomously in neural epithelial cells to limit the amount of neurogenesis and to maintain progenitors Danio rerio
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2.4.1.222 hindbrain isoform lunatic fringe Lfng is expressed by progenitors in neurogenic regions and downregulated in cells that have initiated neuronal differentiation Danio rerio
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Synonyms

EC Number Synonyms Comment Organism
2.4.1.222 LFNG
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 Danio rerio

Expression

EC Number Organism Comment Expression
2.4.1.222 Danio rerio the expression of Lfng does not require Notch activity, but rather is regulated downstream of proneural genes that are widely expressed by neural progenitors additional information

General Information

EC Number General Information Comment Organism
2.4.1.222 physiological function Lfng is required cell autonomously in neural epithelial cells to limit the amount of neurogenesis and to maintain progenitors. Lfng is not required for the role of Notch in interneuronal fate choice, which is mediated by Notch1a. The expression of Lfng does not require Notch activity, but rather is regulated downstream of proneural genes that are widely expressed by neural progenitors Danio rerio