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Literature summary extracted from

  • Holmes, R.
    Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT) (2010), Comp. Biochem. Physiol. D, 5, 45-54.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.75 isozyme AWAT1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis Homo sapiens
2.3.1.75 isozyme AWAT1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis Mus musculus
2.3.1.75 isozyme AWAT2, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis Mus musculus
2.3.1.75 isozyme AWAT2, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis Homo sapiens
2.3.1.75 isozymes AWAT1 and AWAT2, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis Monodelphis domestica

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.22 35320
-
 predicted from sequence analysis, 4237 bp, 327 amino acids, gene location on chromosome 2 Monodelphis domestica
2.3.1.22 37710
-
 predicted from sequence analysis, 10577 bp, 334 amino acids, gene location on chromosome 23 Danio rerio
2.3.1.22 37800
-
 predicted from sequence analysis, 5395 bp, 336 amino acids, gene location on chromosome 5 Danio rerio
2.3.1.22 38010
-
 predicted from sequence analysis, 23470 bp, 330 amino acids, gene location on chromosome 10 Danio rerio
2.3.1.22 38390
-
 predicted from sequence analysis, 30645 bp, 334 amino acids, gene location on chromosome 4 Monodelphis domestica
2.3.1.22 39130
-
 predicted from sequence analysis, 32654 bp, 335 amino acids, gene location on chromosome 7 Monodelphis domestica
2.3.1.75 37573
-
 x * 37573, AWAT1, sequence calculation Mus musculus
2.3.1.75 37759
-
 x * 37759, AWAT1, sequence calculation Homo sapiens
2.3.1.75 38094
-
 x * 38094, AWAT2, sequence calculation Homo sapiens
2.3.1.75 38145
-
 x * 38145, AWAT2, sequence calculation Mus musculus
2.3.1.75 38536
-
 x * 38599, AWAT1, sequence calculation, x * 38536, AWAT2, sequence calculation Monodelphis domestica
2.3.1.75 38599
-
 x * 38599, AWAT1, sequence calculation, x * 38536, AWAT2, sequence calculation Monodelphis domestica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.22 monoacylglycerol + fatty acyl-CoA Monodelphis domestica
-
 diacylglycerol + CoA
-
 ?
2.3.1.22 monoacylglycerol + fatty acyl-CoA Danio rerio
-
 diacylglycerol + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.22 Danio rerio A2BHM7 zebrafish
-
2.3.1.22 Danio rerio B0JZB3 zebrafish
-
2.3.1.22 Danio rerio Q5XJR1 zebrafish
-
2.3.1.22 Monodelphis domestica
-
 opossum
-
2.3.1.75 Homo sapiens Q58HT5 isozyme AWAT1
-
2.3.1.75 Homo sapiens Q6E213 isozyme AWAT2
-
2.3.1.75 Monodelphis domestica
-
 isozymes AWAT1 and AWAT2
-
2.3.1.75 Mus musculus A2ADU9 isozyme AWAT1
-
2.3.1.75 Mus musculus Q6E1M8 isozyme AWAT2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.22 monoacylglycerol + fatty acyl-CoA
-
 Monodelphis domestica diacylglycerol + CoA
-
 ?
2.3.1.22 monoacylglycerol + fatty acyl-CoA
-
 Danio rerio diacylglycerol + CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.75 ? x * 37573, AWAT1, sequence calculation Mus musculus
2.3.1.75 ? x * 37759, AWAT1, sequence calculation Homo sapiens
2.3.1.75 ? x * 38094, AWAT2, sequence calculation Homo sapiens
2.3.1.75 ? x * 38145, AWAT2, sequence calculation Mus musculus
2.3.1.75 ? x * 38599, AWAT1, sequence calculation, x * 38536, AWAT2, sequence calculation Monodelphis domestica
2.3.1.75 More predicted secondary and transmembrane structures of isozyme AWAT1, overview Homo sapiens
2.3.1.75 More predicted secondary and transmembrane structures of isozyme AWAT1, overview Mus musculus
2.3.1.75 More predicted secondary and transmembrane structures of isozyme AWAT2, overview Mus musculus
2.3.1.75 More predicted secondary and transmembrane structures of isozyme AWAT2, overview Homo sapiens
2.3.1.75 More predicted secondary and transmembrane structures of isozymes AWAT1 and AWAT2, overview Monodelphis domestica

Synonyms

EC Number Synonyms Comment Organism
2.3.1.22 MGAT
-
 Monodelphis domestica
2.3.1.22 MGAT
-
 Danio rerio
2.3.1.22 MGAT1
-
 Monodelphis domestica
2.3.1.22 MGAT1
-
 Danio rerio
2.3.1.22 Mgat2
-
 Monodelphis domestica
2.3.1.22 Mgat2
-
 Danio rerio
2.3.1.22 MGAT3
-
 Monodelphis domestica
2.3.1.22 MGAT3
-
 Danio rerio
2.3.1.22 MGOT1
-
 Monodelphis domestica
2.3.1.22 MGOT1
-
 Danio rerio
2.3.1.22 MGOT2
-
 Monodelphis domestica
2.3.1.22 MGOT2
-
 Danio rerio
2.3.1.22 MGOT3
-
 Monodelphis domestica
2.3.1.22 MGOT3
-
 Danio rerio
2.3.1.22 MOGAT1
-
 Monodelphis domestica
2.3.1.22 MOGAT1
-
 Danio rerio
2.3.1.22 MOGAT2
-
 Monodelphis domestica
2.3.1.22 MOGAT2
-
 Danio rerio
2.3.1.22 MOGAT3
-
 Monodelphis domestica
2.3.1.22 MOGAT3
-
 Danio rerio
2.3.1.22 monoacylglycerol acyltransferase
-
 Monodelphis domestica
2.3.1.22 monoacylglycerol acyltransferase
-
 Danio rerio
2.3.1.75 acyl CoA wax alcohol acyltransferase 1
-
 Monodelphis domestica
2.3.1.75 acyl CoA wax alcohol acyltransferase 1
-
 Homo sapiens
2.3.1.75 acyl CoA wax alcohol acyltransferase 1
-
 Mus musculus
2.3.1.75 acyl CoA wax alcohol acyltransferase 2
-
 Mus musculus
2.3.1.75 acyl CoA wax alcohol acyltransferase 2
-
 Homo sapiens
2.3.1.75 acyl CoA wax alcohol acyltransferase 2
-
 Monodelphis domestica
2.3.1.75 AWAT1
-
 Monodelphis domestica
2.3.1.75 AWAT1
-
 Homo sapiens
2.3.1.75 AWAT1
-
 Mus musculus
2.3.1.75 AWAT2
-
 Mus musculus
2.3.1.75 AWAT2
-
 Homo sapiens
2.3.1.75 AWAT2
-
 Monodelphis domestica
2.3.1.75 More the enzyme belongs to the AGAT superfamily Mus musculus
2.3.1.75 More the enzyme belongs to the AGAT superfamily Homo sapiens
2.3.1.75 More the enzyme belongs to the AGAT superfamily Monodelphis domestica

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.3.1.22 Danio rerio predicted from sequence analysis
-
 8.5
2.3.1.22 Monodelphis domestica predicted from sequence analysis
-
 8.8
2.3.1.22 Monodelphis domestica predicted from sequence analysis
-
 8.9
2.3.1.22 Danio rerio predicted from sequence analysis
-
 9
2.3.1.22 Danio rerio predicted from sequence analysis
-
 9.3
2.3.1.22 Monodelphis domestica predicted from sequence analysis
-
 9.6
2.3.1.75 Mus musculus AWAT1, sequence calculation
-
 8.9
2.3.1.75 Monodelphis domestica AWAT1, sequence calculation
-
 9
2.3.1.75 Homo sapiens AWAT1, sequence calculation
-
 9.1
2.3.1.75 Homo sapiens AWAT2, sequence calculation
-
 9.4
2.3.1.75 Mus musculus AWAT2, sequence calculation
-
 9.5
2.3.1.75 Monodelphis domestica AWAT2, sequence calculation
-
 9.8

General Information

EC Number General Information Comment Organism
2.3.1.22 metabolism diacylglyceride synthesis, involved in triglyceride and phospholipid synthesis Monodelphis domestica
2.3.1.22 metabolism diacylglyceride synthesis, involved in triglyceride and phospholipid synthesis Danio rerio
2.3.1.22 physiological function involved in energy storage (fat digestion and absorption), lipoprotein and membrane formation, intracellular signaling for protein kinase activation Monodelphis domestica
2.3.1.22 physiological function involved in energy storage (fat digestion and absorption), lipoprotein and membrane formation, intracellular signaling for protein kinase activation Danio rerio
2.3.1.22 physiological function involvid in energy storage (fat digestion and absorption), lipoprotein and membrane formation, intracellular signaling for protein kinase activation Danio rerio