Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Berdis, A.
    Mechanisms of DNA polymerases (2009), Chem. Rev., 109, 2862-2879.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.7 D112A/E114A the mutant T4 DNA polymerases is defective in 3'-5' exonuclease activity and has a 1000fold increase in the development of spontaneous mutations compared to wild type polymerase Tequatrovirus T4
2.7.7.7 D219A the mutant T4 DNA polymerases is defective in 3'-5' exonuclease activity and has a 1000fold increase in the development of spontaneous mutations compared to wild type polymerase Tequatrovirus T4
2.7.7.7 D324A the mutant T4 DNA polymerases is defective in 3'-5' exonuclease activity and has a 1000fold increase in the development of spontaneous mutations compared to wild type polymerase, the exonuclease activity of the D324A mutant is 100000-fold lower than wild type polymerase Tequatrovirus T4

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.7 Bacillus subtilis
-
-
-
2.7.7.7 Escherichia coli
-
-
-
2.7.7.7 Escherichia phage RB69
-
-
-
2.7.7.7 Escherichia phage T7
-
-
-
2.7.7.7 Geobacillus stearothermophilus
-
-
-
2.7.7.7 Homo sapiens
-
-
-
2.7.7.7 Tequatrovirus T4
-
-
-
2.7.7.7 Thermus aquaticus P19821
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Bacillus subtilis diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Escherichia coli diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Homo sapiens diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Geobacillus stearothermophilus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Tequatrovirus T4 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Escherichia phage T7 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Escherichia phage RB69 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Thermus aquaticus diphosphate + DNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.7 DNA polymerase
-
 Bacillus subtilis
2.7.7.7 DNA polymerase
-
 Escherichia coli
2.7.7.7 DNA polymerase
-
 Geobacillus stearothermophilus
2.7.7.7 DNA polymerase
-
 Tequatrovirus T4
2.7.7.7 DNA polymerase
-
 Escherichia phage T7
2.7.7.7 DNA polymerase
-
 Escherichia phage RB69
2.7.7.7 DNA polymerase
-
 Thermus aquaticus
2.7.7.7 DNA polymerase I
-
 Homo sapiens
2.7.7.7 Pol
-
 Bacillus subtilis
2.7.7.7 Pol
-
 Escherichia coli
2.7.7.7 Pol
-
 Geobacillus stearothermophilus
2.7.7.7 Pol
-
 Tequatrovirus T4
2.7.7.7 Pol
-
 Escherichia phage T7
2.7.7.7 Pol
-
 Escherichia phage RB69
2.7.7.7 Pol
-
 Thermus aquaticus
2.7.7.7 Pol I
-
 Homo sapiens