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Literature summary extracted from

  • Amo, T.; Kawanishi, N.; Uchida, M.; Fujita, H.; Oyanagi, E.; Utsumi, T.; Ogino, T.; Inoue, K.; Shuin, T.; Utsumi, K.; Sasaki, J.
    Mechanism of cell death by 5-aminolevulinic acid-based photodynamic action and its enhancement by ferrochelatase inhibitors in human histiocytic lymphoma cell line U937 (2009), Cell Biochem. Funct., 27, 503-515.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.98.1.1 medicine photodynamic therapy (PDT) for tumors is based on the tumor-selective accumulation of a photosensitizer, protoporphyrin IX (PpIX), followed by irradiation with visible light, PpIX accumulation in 5-aminolevulinic acid, treated U937 cells is increased by the inhibition of ferrochelatase Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.98.1.1 deferoxamine
-
 Homo sapiens
4.98.1.1 Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.98.1.1 protoporphyrin IX + Fe2+ Homo sapiens
-
 protoheme IX + 2 H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.98.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.98.1.1 protoporphyrin IX + Fe2+
-
 Homo sapiens protoheme IX + 2 H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.98.1.1 ferrochelatase
-
 Homo sapiens