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Literature summary extracted from

  • Suzuki, Y.; Takahashi, H.; Fukuda, M.; Hino, H.; Kobayashi, K.; Tanaka, J.; Ishii, E.
    Beta-hydroxybutyrate alters GABA-transaminase activity in cultured astrocytes (2009), Brain Res., 1268, 17-23.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Rattus norvegicus P50554
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.19 astrocyte
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 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
 Rattus norvegicus 4-oxobutanoate + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.19 GABA transaminase
-
 Rattus norvegicus
2.6.1.19 GABA-T
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 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.19 pyridoxal 5'-phosphate
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
2.6.1.19 Rattus norvegicus when beta-hydroxybutyrate (10 mM) is added to culture medium, GABA-transaminase mRNA expression is significantly suppressed in time- and dose-dependent manners, GABA-T enzymatic activity in beta-hydroxybutyrate-treated astrocytes is also suppressed, in accordance with its gene expression down