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Literature summary extracted from

  • Sfaxi, I.H.; Ferraro, D.; Fasano, E.; Pani, G.; Limam, F.; Marzouki, M.N.
    Inhibitory effects of a manganese superoxide dismutase isolated from garlic (Allium sativum L.) on in vitro tumoral cell growth (2009), Biotechnol. Prog., 25, 257-264.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 2 O2.- + 2 H+ Allium sativum
-
 O2 + H2O2
-
 ?
1.15.1.1 additional information Allium sativum the enzyme is involved in activation and modulation of phospho-extracellular signal-regulated kinases proteins and in the control of several biological processes including cell proliferation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Allium sativum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.15.1.1 native enzyme from bulbs by ammonium sulfate fractionation, dialysis, gel filtration, and anion exchange chromatography Allium sativum

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.15.1.1 bulb
-
 Allium sativum
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.15.1.1 89
-
 purified enzyme Allium sativum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 2 O2.- + 2 H+
-
 Allium sativum O2 + H2O2
-
 ?
1.15.1.1 2 O2.- + 2 H+ activity determination by the epinephrine assay: at alkaline pH, superoxide anion O2- causes the oxidation of epinephrine to adrenochrome, SOD competes with this reaction by decreasing the adrenochrome formation Allium sativum O2 + H2O2
-
 ?
1.15.1.1 additional information the enzyme is involved in activation and modulation of phospho-extracellular signal-regulated kinases proteins and in the control of several biological processes including cell proliferation Allium sativum ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 manganese superoxide dismutase
-
 Allium sativum
1.15.1.1 MnSOD
-
 Allium sativum
1.15.1.1 SOD
-
 Allium sativum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.15.1.1 25
-
 assay at Allium sativum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.15.1.1 10.2
-
 assay at Allium sativum

General Information

EC Number General Information Comment Organism
1.15.1.1 physiological function the exogenous manganese superoxide dismutase is able to modify the intracellular level of reactive oxygen species by eliminating superoxide anion and producing hydrogen peroxide. The cell viability of the two tumoral cell lines, porcine aortic endothelial cells and B16F0 mouse melanoma cells, exposed to the enzyme, is not significantly affected but the cell multiplication is arrested. The enzyme is involved in the control of several biological processes including cell proliferation Allium sativum