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Literature summary extracted from

  • Onaka, H.; Taniguchi, S.; Igarashi, Y.; Furumai, T.
    Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243 (2003), Biosci. Biotechnol. Biochem., 67, 127-138.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.98.2 7-chloroindole-3-pyruvic acid + 7-chlorotryptophan + O2 Lentzea aerocolonigenes RebD is involved in the construction of a bisindole structure by catalyzing a coupling reaction between 7-chlorotryptophan and 7-chloroindole-3-pyruvic acid 11,11'-dichlorochromopyrrolic acid + NH3 + H2O
-
 ?
1.21.98.2 7-chloroindole-3-pyruvic acid + 7-chlorotryptophan + O2 Lentzea aerocolonigenes ATCC 39243 RebD is involved in the construction of a bisindole structure by catalyzing a coupling reaction between 7-chlorotryptophan and 7-chloroindole-3-pyruvic acid 11,11'-dichlorochromopyrrolic acid + NH3 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.98.2 Lentzea aerocolonigenes Q8KHV6
-
-
1.21.98.2 Lentzea aerocolonigenes ATCC 39243 Q8KHV6
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-
4.3.3.5 Lentzea aerocolonigenes
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 strain ATCC 39243
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.98.2 7-chloroindole-3-pyruvic acid + 7-chlorotryptophan + O2 RebD is involved in the construction of a bisindole structure by catalyzing a coupling reaction between 7-chlorotryptophan and 7-chloroindole-3-pyruvic acid Lentzea aerocolonigenes 11,11'-dichlorochromopyrrolic acid + NH3 + H2O
-
 ?
1.21.98.2 7-chloroindole-3-pyruvic acid + 7-chlorotryptophan + O2 RebD is involved in the construction of a bisindole structure by catalyzing a coupling reaction between 7-chlorotryptophan and 7-chloroindole-3-pyruvic acid Lentzea aerocolonigenes ATCC 39243 11,11'-dichlorochromopyrrolic acid + NH3 + H2O
-
 ?
4.3.3.5 rebeccamycin aglycone + beta-D-glucose
-
 Lentzea aerocolonigenes rebeccamycin + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.98.2 RebD
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 Lentzea aerocolonigenes

General Information

EC Number General Information Comment Organism
4.3.3.5 physiological function enzyme is part of the biosynthetic gene cluster for synthesis of rebeccamycin in Lechevalieria aerocolonigenes ATCC 39243. Besides N-glycosyltransferase RebG, genes encode a monooxygenase RebC, methyltransferase RebM, transcriptional activator RebR, and halogenase RebH. A RebG gene disruption mutant produces the rebeccamycin aglycone but not rebeccamycin itself Lentzea aerocolonigenes