Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Scherpenzeel, M.; van den Berg, R.; Donker-Koopman, W.; Liskamp, R.; Aerts, J.; Overkleeft, H.; Pieters, R.
    Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase (2010), Bioorg. Med. Chem., 18, 267-273.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.21 1-deoxynojirimycin
-
 Prunus dulcis
3.2.1.21 4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide
-
 Prunus dulcis
3.2.1.21 N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin
-
 Prunus dulcis
3.2.1.45 1-deoxynojirimycin
-
 Homo sapiens
3.2.1.45 4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide
-
 Homo sapiens
3.2.1.45 N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.45 lysosome GBA Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.45 glucosylceramide + H2O Homo sapiens
-
 beta-D-glucose + ceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.21 Prunus dulcis
-
-
-
3.2.1.45 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.21 seed
-
 Prunus dulcis
-
3.2.1.45 placenta non-lysosomal GBA2 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.21 4-methylumbelliferyl-beta-D-glucoside + H2O
-
 Prunus dulcis 4-methylumbelliferone + beta-D-glucose
-
 ?
3.2.1.45 4-methylumbelliferyl-beta-D-glucoside + H2O
-
 Homo sapiens 4-methylumbelliferone + beta-D-glucose
-
 ?
3.2.1.45 glucosylceramide + H2O
-
 Homo sapiens beta-D-glucose + ceramide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.45 Ceredase commercial preparation Homo sapiens
3.2.1.45 Cerezyme commercial preparation Homo sapiens
3.2.1.45 GBA lysosomal glucocerebrosidase Homo sapiens
3.2.1.45 GBA2 non-lysosomal glucoceramidase Homo sapiens
3.2.1.45 glucocerebrosidase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.21 0.0013
-
 N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin
-
 Prunus dulcis
3.2.1.21 0.0064
-
 4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide
-
 Prunus dulcis
3.2.1.21 0.167
-
 1-deoxynojirimycin
-
 Prunus dulcis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.45 0.00002
-
 non-lysosomal GBA2 Homo sapiens N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin
3.2.1.45 0.000075
-
 non-lysosomal GBA2 Homo sapiens 4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide
3.2.1.45 0.00035
-
 lysosomal GBA Homo sapiens N-{3-[4-(cyanomethoxy)benzoyl]benzoyl}propylamido-1-deoxynojirimycin
3.2.1.45 0.00165
-
 lysosomal GBA Homo sapiens 4-[4-(cyanomethoxy)phenyl]-4-oxo-N-{3-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]propyl}butanamide
3.2.1.45 0.0288
-
 non-lysosomal GBA2 Homo sapiens 1-deoxynojirimycin
3.2.1.45 0.506
-
 lysosomal GBA Homo sapiens 1-deoxynojirimycin