Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Dillon, G.P.; Gaynor, J.M.; Khan, D.; Carolan, C.G.; Ryder, S.A.; Marquez, J.F.; Reidy, S.; Gilmer, J.F.
    Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability (2010), Bioorg. Med. Chem., 18, 1045-1053.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.8 2-(benzylaminocarbonyloxy)-5-(phenylcarbonyloxyimino-)-1,4 3,6-dianhydro-D-glucitol 9% inhibition at 0.1 mM Homo sapiens
3.1.1.8 2-(benzylaminocarbonyloxy)-5-deoxy, 5-dehydro-((ethyloxycarbonyl)ene-)-1,4 3,6-dianhydro-D-glucitol 4.9% inhibition at 0.1 mM Homo sapiens
3.1.1.8 2-(benzylaminocarbonyloxy)-5-deoxy-5-phenylcarbonylamino-1,4 3,6-dianhydro-D-glucitol 46% inhibition at 0.1 mM Homo sapiens
3.1.1.8 2-(benzylaminocarbonyloxy)-5-deoxy-L-xylohex-6-enitol 9.8% inhibition at 0.1 mM Homo sapiens
3.1.1.8 2-(benzylaminocarbonyloxy)-5-keto-1,4 3,6-dianhydro-D-glucitol 10% inhibition at 0.1 mM Homo sapiens
3.1.1.8 2-(benzylaminocarbonyloxy)-5-ketoxime-1,4 3,6-dianhydro-D-glucitol 83% inhibition at 0.1 mM Homo sapiens
3.1.1.8 2-(benzylaminocarbonyloxy)-5-O-(phenylpropyloxy)-1,4 3,6-dianhydro-D-glucitol 55% inhibition at 0.1 mM Homo sapiens
3.1.1.8 2-(benzylaminocarbonyloxy)-5-O-benzyl-1,4 3,6-dianhydro-D-glucitol 55% inhibition at 0.1 mM Homo sapiens
3.1.1.8 5-deoxy-5-azido-1,4 3,6-dianhydro-D-glucitol 5% inhibition at 0.1 mM Homo sapiens
3.1.1.8 7-exo-(benzylaminocarbonyloxy)-3-oxo-2,5,9-trioxabicyclo [4.3.0] nonane 10% inhibition at 0.1 mM Homo sapiens
3.1.1.8 isosorbide-di-(4-nitrophenyl carbamate)
-
 Homo sapiens
3.1.1.8 isosorbide-di-(benzylcarbamate) 77% inhibition at 0.1 mM Homo sapiens
3.1.1.8 isosorbide-di-(butylcarbamate) 13% inhibition at 0.1 mM Homo sapiens
3.1.1.8 isosorbide-di-(ethylcarbamate)
-
 Homo sapiens
3.1.1.8 isosorbide-di-(propylcarbamate) 28% inhibition at 0.1 mM Homo sapiens
3.1.1.8 isosorbide-di-phenylcarbamate 77% inhibition at 0.1 mM Homo sapiens
3.1.1.8 N-methyl-7-exo-(benzylaminocarbonyloxy-)-3-oxo-5,9-dioxa-2-azabicyclo[4.3.0] nonane 6.5% inhibition at 0.1 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.8 butyrylthiocholine + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.8 BChE
-
 Homo sapiens
3.1.1.8 butyrylcholinesterase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.8 0.0054
-
-
 Homo sapiens isosorbide-di-(4-nitrophenyl carbamate)
3.1.1.8 0.0065
-
-
 Homo sapiens isosorbide-di-(ethylcarbamate)