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Literature summary extracted from

  • Pearson, M.S.; Floquet, N.; Bello, C.; Vogel, P.; Plantier-Royon, R.; Szymoniak, J.; Bertus, P.; Behr, J.B.
    The spirocyclopropyl moiety as a methyl surrogate in the structure of L-fucosidase and L-rhamnosidase inhibitors (2009), Bioorg. Med. Chem., 17, 8020-8026.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.40 (1R,2S,6R,8S,8aS)-6-methyloctahydroindolizine-1,2,8-triol
-
 Penicillium decumbens
3.2.1.40 (2S,3S,4S)-2-methyl-3,4-dihydro-2H-pyrrole-3,4-diol
-
 Penicillium decumbens
3.2.1.40 (2S,3S,4S)-2-methylpyrrolidine-3,4-diol
-
 Penicillium decumbens
3.2.1.40 (3S,4R)-3,4-dihydroxy-5-spirocyclopropyl-DELTA-pyrroline
-
 Penicillium decumbens
3.2.1.40 (3S,4S)-3,4-dihydroxy-5-spirocyclopropyl-DELTA-pyrroline 72% inhibition at 1 mM Penicillium decumbens
3.2.1.40 (6S,7S,8S)-4-azaspiro[2.5]octane-6,7,8-triol 72% inhibition at 1 mM Penicillium decumbens
3.2.1.40 additional information not inhibited by deoxyrhamnojirimycin and 5-C-spirocyclopropyl-(5-demethyl-1-deoxy)-L-fuconojirimycin Penicillium decumbens
3.2.1.40 [4-([[(2S,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]methyl]amino)-5-hydroxy-6-methylpyridin-2-yl]methyl dihydrogen phosphate
-
 Penicillium decumbens
3.2.1.40 [4-([[(2S,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl]amino)-5-hydroxy-6-methylpyridin-2-yl]methyl dihydrogen phosphate
-
 Penicillium decumbens

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.40 Penicillium decumbens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.40 4-nitrophenyl alpha-L-rhamnoside + H2O
-
 Penicillium decumbens alpha-L-rhamnose + 4-nitrophenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.40 L-rhamnosidase
-
 Penicillium decumbens
3.2.1.40 naringinase
-
 Penicillium decumbens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.40 0.00003
-
 (1R,2S,6R,8S,8aS)-6-methyloctahydroindolizine-1,2,8-triol
-
 Penicillium decumbens
3.2.1.40 0.00014
-
 (2S,3S,4S)-2-methyl-3,4-dihydro-2H-pyrrole-3,4-diol
-
 Penicillium decumbens
3.2.1.40 0.003
-
 [4-([[(2S,3S,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl]amino)-5-hydroxy-6-methylpyridin-2-yl]methyl dihydrogen phosphate
-
 Penicillium decumbens
3.2.1.40 0.0032
-
 [4-([[(2S,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]methyl]amino)-5-hydroxy-6-methylpyridin-2-yl]methyl dihydrogen phosphate
-
 Penicillium decumbens
3.2.1.40 0.0055
-
 (2S,3S,4S)-2-methylpyrrolidine-3,4-diol
-
 Penicillium decumbens
3.2.1.40 0.057
-
 (3S,4R)-3,4-dihydroxy-5-spirocyclopropyl-DELTA-pyrroline
-
 Penicillium decumbens