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Literature summary extracted from

  • Wnuk, S.F.; Robert, J.; Sobczak, A.J.; Meyers, B.P.; Malladi, V.L.; Zhu, J.; Gopishetty, B.; Pei, D.
    Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position (2009), Bioorg. Med. Chem., 17, 6699-6706.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.21 S-(3,5-dideoxy-3-fluoro-1-O-methyl-D-xylofuranos-5-yl)-L-homocysteine
-
 Bacillus subtilis
4.4.1.21 S-(3,5-dideoxy-3-fluoro-D-xylofuranos-5-yl)-L-homocysteine
-
 Bacillus subtilis
4.4.1.21 S-(3,5-dideoxy-D-erythro-pentofuranos-5-yl)homocysteine
-
 Bacillus subtilis
4.4.1.21 S-(5-deoxy-3-deoxy-3-bromo-D-xylofuranos-5-yl)-L-homocysteine
-
 Bacillus subtilis
4.4.1.21 S-(5-deoxy-3-deoxy-3-fluoro-D-xylofuranos-5-yl)-L-homocysteine
-
 Bacillus subtilis
4.4.1.21 S-(5-deoxy-3-O-methyl-D-ribofuranos-5-yl)homocysteine
-
 Bacillus subtilis
4.4.1.21 S-(5-deoxy-3-O-methyl-D-xylofuranos-5-yl)homocysteine
-
 Bacillus subtilis
4.4.1.21 S-(5-deoxy-D-xylofuranos-5-yl)-L-homocysteine
-
 Bacillus subtilis

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.21 Bacillus subtilis O34667
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.21 S-ribosylhomocysteine assay at pH 7.0, 23°C Bacillus subtilis L-homocysteine + (S)-4,5-dihydroxy-2,3-pentanedione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.21 LuxS
-
 Bacillus subtilis
4.4.1.21 S-ribosylhomocysteinase
-
 Bacillus subtilis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.4.1.21 23
-
 assay at Bacillus subtilis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.4.1.21 7
-
 assay at Bacillus subtilis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.4.1.21 0.0042
-
 S-(5-deoxy-D-xylofuranos-5-yl)-L-homocysteine pH 7.0, 23°C Bacillus subtilis
4.4.1.21 0.0077
-
 S-(3,5-dideoxy-3-fluoro-D-xylofuranos-5-yl)-L-homocysteine pH 7.0, 23°C Bacillus subtilis
4.4.1.21 0.0079
-
 S-(5-deoxy-3-deoxy-3-bromo-D-xylofuranos-5-yl)-L-homocysteine pH 7.0, 23°C Bacillus subtilis
4.4.1.21 0.0106
-
 S-(5-deoxy-3-deoxy-3-fluoro-D-xylofuranos-5-yl)-L-homocysteine pH 7.0, 23°C Bacillus subtilis
4.4.1.21 0.042
-
 S-(5-deoxy-3-O-methyl-D-ribofuranos-5-yl)homocysteine pH 7.0, 23°C Bacillus subtilis
4.4.1.21 0.042
-
 S-(3,5-dideoxy-3-fluoro-1-O-methyl-D-xylofuranos-5-yl)-L-homocysteine pH 7.0, 23°C Bacillus subtilis
4.4.1.21 0.055
-
 S-(3,5-dideoxy-D-erythro-pentofuranos-5-yl)homocysteine pH 7.0, 23°C Bacillus subtilis
4.4.1.21 0.066
-
 S-(5-deoxy-3-O-methyl-D-xylofuranos-5-yl)homocysteine pH 7.0, 23°C Bacillus subtilis

General Information

EC Number General Information Comment Organism
4.4.1.21 physiological function produces precursor of type 2 autoinducer for bacterial cell-cell communication Bacillus subtilis