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Literature summary extracted from

  • Gao, F.; Yan, X.; Zahr, O.; Larsen, A.; Vong, K.; Auclair, K.
    Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside-CoA bisubstrates as mechanistic probes for aminoglycoside N-6-acetyltransferase (2008), Bioorg. Med. Chem. Lett., 18, 5518-5522.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.82 (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[(2-sulfanylethyl)sulfonyl]amino]-alpha-D-glucopyranoside-S-CoA
-
 Enterococcus faecium
2.3.1.82 (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[(dioxidosulfanyl)acetyl]amino]-alpha-D-glucopyranoside-S-CoA
-
 Enterococcus faecium
2.3.1.82 (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[(oxidosulfanyl)acetyl]amino]-alpha-D-glucopyranoside-S-CoA
-
 Enterococcus faecium
2.3.1.82 (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[3-(dioxidosulfanyl)propanoyl]amino]-alpha-D-glucopyranoside-S-CoA
-
 Enterococcus faecium
2.3.1.82 (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[3-(oxidosulfanyl)propanoyl]amino]-alpha-D-glucopyranoside-S-CoA
-
 Enterococcus faecium

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.82 Enterococcus faecium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.82 acetyl-CoA + neamine
-
 Enterococcus faecium CoA + 6'-N-acetylneamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.82 AAC(6')-Ii
-
 Enterococcus faecium
2.3.1.82 aminoglycoside N-6'-acetyltransferase
-
 Enterococcus faecium
2.3.1.82 aminoglycoside N-6'-acetyltransferase Ii
-
 Enterococcus faecium

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.82 acetyl-CoA
-
 Enterococcus faecium

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.82 0.00006
-
 (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[(oxidosulfanyl)acetyl]amino]-alpha-D-glucopyranoside-S-CoA competitive inhibition Enterococcus faecium
2.3.1.82 0.00009
-
 (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[3-(dioxidosulfanyl)propanoyl]amino]-alpha-D-glucopyranoside-S-CoA competitive inhibition Enterococcus faecium
2.3.1.82 0.00027
-
 (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[(dioxidosulfanyl)acetyl]amino]-alpha-D-glucopyranoside-S-CoA competitive inhibition Enterococcus faecium
2.3.1.82 0.0016
-
 (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[(2-sulfanylethyl)sulfonyl]amino]-alpha-D-glucopyranoside-S-CoA competitive inhibition Enterococcus faecium
2.3.1.82 0.002
-
 (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[3-(oxidosulfanyl)propanoyl]amino]-alpha-D-glucopyranoside-S-CoA competitive inhibition Enterococcus faecium