EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
5.3.99.4 | interleukin-1 | - |
Homo sapiens | |
5.3.99.4 | interleukin-6 | - |
Homo sapiens | |
5.3.99.4 | TNFalpha | - |
Homo sapiens |
EC Number | Application | Comment | Organism |
---|---|---|---|
5.3.99.4 | medicine | prostacyclin synthase may be chemopreventive in cancer | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
5.3.99.4 | - |
Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.3.99.4 | rofecoxib | - |
Homo sapiens | |
5.3.99.5 | ozagrel | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
5.3.99.4 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
5.3.99.4 | nuclear membrane | - |
Homo sapiens | 31965 | - |
5.3.99.4 | plasma membrane | - |
Homo sapiens | 5886 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
5.3.99.4 | 52000 | - |
- |
Homo sapiens |
5.3.99.5 | 60000 | - |
SDS-PAGE | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.4 | Prostaglandin H2 | Homo sapiens | - |
Prostaglandin I2 | - |
? | |
5.3.99.5 | prostaglandin H2 | Homo sapiens | - |
thromboxane A2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.3.99.4 | Homo sapiens | - |
- |
- |
5.3.99.5 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
5.3.99.4 | - |
Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
5.3.99.4 | lung cancer cell | - |
Homo sapiens | - |
5.3.99.4 | myometrial cell | - |
Homo sapiens | - |
5.3.99.4 | neuron | - |
Homo sapiens | - |
5.3.99.4 | smooth muscle cell | - |
Homo sapiens | - |
5.3.99.4 | umbilical vein endothelial cell | - |
Homo sapiens | - |
5.3.99.4 | vascular endothelial cell | - |
Homo sapiens | - |
5.3.99.5 | A-549 cell | - |
Homo sapiens | - |
5.3.99.5 | breast carcinoma cell | - |
Homo sapiens | - |
5.3.99.5 | colorectal cancer cell | - |
Homo sapiens | - |
5.3.99.5 | lung | in normal lung tissue, TXS is moderately expressed in bronchial epithelial cells and weakly expressed in vascular smooth muscle cells | Homo sapiens | - |
5.3.99.5 | lung cancer cell | - |
Homo sapiens | - |
5.3.99.5 | non-small cell lung cancer cell | - |
Homo sapiens | - |
5.3.99.5 | papillary thyroid carcinoma cell | - |
Homo sapiens | - |
5.3.99.5 | prostate cancer cell | - |
Homo sapiens | - |
5.3.99.5 | renal carcinoma cell | - |
Homo sapiens | - |
5.3.99.5 | urinary bladder cancer cell | - |
Homo sapiens | - |
5.3.99.5 | uterine cancer cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.4 | Prostaglandin H2 | - |
Homo sapiens | Prostaglandin I2 | - |
? | |
5.3.99.5 | prostaglandin H2 | - |
Homo sapiens | thromboxane A2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.3.99.4 | prostacyclin synthase | - |
Homo sapiens |
5.3.99.5 | thromboxane A2 synthase | - |
Homo sapiens |
5.3.99.5 | TXS | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
5.3.99.5 | heme | - |
Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
5.3.99.4 | Homo sapiens | a dramatic loss in PGIS mRNA levels is observed in primary lung tumor samples | down |
5.3.99.4 | Homo sapiens | PGIS mRNA and protein expression is increased in response to mechanical cyclical stretch in both spinal ligament and uterine myometrial cells, up-regulation is observed in umbilical vein endothelial cell treated with a thromboxane analogue | up |
5.3.99.5 | Homo sapiens | an overall increase in TXS expression is observed in tumor tissues relative to normal, increased TXS expression at mRNA level is reported in renal cell carcinoma, breast carcinoma, prostate cancer and uterine cancer when compared with matched normal tissues | up |