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Literature summary extracted from

  • Wang, H.; Wang, Y.
    6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo (2009), Biochemistry, 48, 2290-2299.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.37 5-aza-2'-deoxycytidine
-
 Haemophilus parainfluenzae
2.1.1.37 5-aza-2'-deoxycytidine
-
 Homo sapiens
2.1.1.37 6-thioguanine incorporation of 6-thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Presence of 6-thioguanine at the unmethylated CpG site abolished almost completely the methylation of its 5' adjacent cytosine by HpaII Haemophilus parainfluenzae
2.1.1.37 6-thioguanine incorporation of 6-thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Presence of 6-thioguanine at the unmethylated CpG site abolished almost completely the methylation of its 5' adjacent cytosine by DNMT1 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.37 DNA + S-adenosyl-L-methionine Homo sapiens
-
 DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.37 DNA + S-adenosyl-L-methionine Haemophilus parainfluenzae
-
 DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.37 Haemophilus parainfluenzae
-
-
-
2.1.1.37 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.37 JURKAT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.37 DNA + S-adenosyl-L-methionine
-
 Homo sapiens DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.37 DNA + S-adenosyl-L-methionine
-
 Haemophilus parainfluenzae DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.37 DNA + S-adenosyl-L-methionine double-stranded DNA substrates with CpG site containing 8-oxo-7,8-dihydroguanine, resulting in diminished enzymatic methylation of its 5' neighboring cytosine, or 8-oxoG or O6-methylguanine in the CpG site, overview Homo sapiens DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.37 DNA + S-adenosyl-L-methionine double-stranded DNA substrates with CpG site, overview Haemophilus parainfluenzae DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.37 Dnmt1
-
 Homo sapiens
2.1.1.37 HpaII
-
 Haemophilus parainfluenzae

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.1.1.37 65
-
 20 min, inactivation Homo sapiens
2.1.1.37 65
-
 20 min, inactivation Haemophilus parainfluenzae

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.37 S-adenosyl-L-methionine
-
 Homo sapiens
2.1.1.37 S-adenosyl-L-methionine
-
 Haemophilus parainfluenzae

General Information

EC Number General Information Comment Organism
2.1.1.37 physiological function the enzyme activity is involved in the epigenetic pathway of gene regulation Homo sapiens
2.1.1.37 physiological function the enzyme activity is involved in the epigenetic pathway of gene regulation Haemophilus parainfluenzae