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Literature summary extracted from

  • Milek, M.; Karas Kuzelicki, N.; Smid, A.; Mlinaric-Rascan, I.
    S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts (2009), Biochem. Pharmacol., 77, 1845-1853.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.67 S-adenosyl-L-methionine S-adenosyl-L-methionine acts as a positive modulator of TPMT activity, the effect of S-adenosyl-L-methionine appears to be restricted to protein stabilisation rather than an increase of TPMT expression Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.67 6-Mercaptopurine TPMT activity and protein levels are diminished in cells incubated with 6-mercaptopurine Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 lymphoblast
-
 Homo sapiens
-
2.1.1.67 MOLT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
2.1.1.67 S-adenosyl-L-methionine + thioinosine monophosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + methylthioinosine monophosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.67 thiopurine methyltransferase
-
 Homo sapiens
2.1.1.67 TPMT
-
 Homo sapiens