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Literature summary extracted from

  • Senggunprai, L.; Yoshinari, K.; Yamazoe, Y.
    Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases (2009), Biochem. J., 422, 455-462.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.1 expressed in Escherichia coli BL21(DE3) cells Mus musculus
2.8.2.1 expressed in Escherichia coli BL21(DE3) cells Homo sapiens
2.8.2.3 expressed in Escherichia coli BL21(DE3) cells Mus musculus
2.8.2.4 expressed in Escherichia coli BL21(DE3) cells Homo sapiens
2.8.2.14 expressed in Escherichia coli BL21(DE3) cells Homo sapiens
2.8.2.15 expressed in Escherichia coli BL21(DE3) cells Mus musculus
2.8.2.15 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.1 2,6-Dichloro-4-nitrophenol non-specific SULT inhibitor Homo sapiens
2.8.2.1 2,6-Dichloro-4-nitrophenol non-specific SULT inhibitor; non-specific SULT inhibitor Mus musculus
2.8.2.1 5,7-dichlorokynurenic acid
-
Homo sapiens
2.8.2.1 5,7-dichlorokynurenic acid
-
Mus musculus
2.8.2.1 gavestinel i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt; i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt Homo sapiens
2.8.2.1 gavestinel i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt; i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt Mus musculus
2.8.2.1 Kynurenic acid
-
Homo sapiens
2.8.2.1 Kynurenic acid exhibits selective inhibitory effects on Sult1b1-mediated sulfation of various compounds with IC50 values in the low micromolar range, Mus musculus
2.8.2.1 L689,560 i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline; i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline Homo sapiens
2.8.2.1 L689,560 i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline; i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline Mus musculus
2.8.2.1 L701,324 i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone; i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone Homo sapiens
2.8.2.1 L701,324 i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone; i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone Mus musculus
2.8.2.1 Mefenamic acid
-
Homo sapiens
2.8.2.1 Mefenamic acid
-
Mus musculus
2.8.2.3 5,7-dichlorokynurenic acid
-
Mus musculus
2.8.2.3 gavestinel i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt Mus musculus
2.8.2.3 Kynurenic acid
-
Mus musculus
2.8.2.3 L689,560 i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline Mus musculus
2.8.2.3 L701,324 i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone Mus musculus
2.8.2.3 Mefenamic acid
-
Mus musculus
2.8.2.4 5,7-dichlorokynurenic acid
-
Homo sapiens
2.8.2.4 gavestinel i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt Homo sapiens
2.8.2.4 Kynurenic acid
-
Homo sapiens
2.8.2.4 L689,560 i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline Homo sapiens
2.8.2.4 L701,324 i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone Homo sapiens
2.8.2.4 Mefenamic acid
-
Homo sapiens
2.8.2.14 2,6-Dichloro-4-nitrophenol non-specific SULT inhibitor Homo sapiens
2.8.2.14 5,7-dichlorokynurenic acid
-
Homo sapiens
2.8.2.14 gavestinel i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt Homo sapiens
2.8.2.14 Kynurenic acid
-
Homo sapiens
2.8.2.14 L689,560 i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline Homo sapiens
2.8.2.14 L701,324 i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone Homo sapiens
2.8.2.14 Mefenamic acid
-
Homo sapiens
2.8.2.15 2,6-Dichloro-4-nitrophenol non-specific SULT inhibitor Homo sapiens
2.8.2.15 5,7-dichlorokynurenic acid
-
Homo sapiens
2.8.2.15 5,7-dichlorokynurenic acid
-
Mus musculus
2.8.2.15 gavestinel i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt Homo sapiens
2.8.2.15 gavestinel i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt Mus musculus
2.8.2.15 Kynurenic acid exhibits selective inhibitory effects on Sult1b1-mediated sulfation of various compounds with IC50 values in the low micromolar range Homo sapiens
2.8.2.15 Kynurenic acid
-
Mus musculus
2.8.2.15 L689,560 i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline Homo sapiens
2.8.2.15 L689,560 i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline Mus musculus
2.8.2.15 L701,324 i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone Homo sapiens
2.8.2.15 L701,324 i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone Mus musculus
2.8.2.15 Mefenamic acid
-
Homo sapiens
2.8.2.15 Mefenamic acid
-
Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.1 0.00035
-
p-nitrophenol isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus
2.8.2.1 0.00041
-
4-nitrophenol isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens
2.8.2.1 0.00053
-
xanthurenic acid isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus
2.8.2.1 0.00099
-
1-naphthol isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens
2.8.2.1 0.0026
-
beta-estradiol isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens
2.8.2.1 0.0053
-
dopamine isoform SULT1A3, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens
2.8.2.1 0.0433
-
xanthurenic acid isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens
2.8.2.1 0.0509
-
xanthurenic acid isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus
2.8.2.1 0.0529
-
p-nitrophenol isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus
2.8.2.1 0.0939
-
L-triiodothyronine isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus
2.8.2.4 0.00033
-
beta-estradiol isoform SULT1E1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens
2.8.2.14 0.0014
-
dehydroepiandrosterone isoform SULT2A1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens
2.8.2.15 0.0012
-
1-naphthol isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens
2.8.2.15 0.0051
-
dehydroepiandrosterone isoform SULT2A1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus
2.8.2.15 0.0063
-
xanthurenic acid isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens
2.8.2.15 0.015
-
xanthurenic acid isoform Sult1d1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus
2.8.2.15 0.0209
-
3,4-dihydroxyphenylacetic acid isoform Sult1d1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus
2.8.2.15 0.0399
-
4-nitrophenol isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens
2.8.2.15 0.145
-
L-triiodothyronine isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens
2.8.2.15 0.206
-
xanthurenic acid isoform SULT1C2, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens
2.8.2.15 0.238
-
3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine isoform Sult2a1, in 50 mM Tris/HCl buffer, pH 10.0, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.1 cytosol
-
Mus musculus 5829
-
2.8.2.1 cytosol
-
Homo sapiens 5829
-
2.8.2.3 cytosol
-
Mus musculus 5829
-
2.8.2.4 cytosol
-
Homo sapiens 5829
-
2.8.2.14 cytosol
-
Homo sapiens 5829
-
2.8.2.15 cytosol
-
Mus musculus 5829
-
2.8.2.15 cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + 1-naphthol Mus musculus
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + 1-naphthol Homo sapiens
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + 4-nitrophenol Mus musculus
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + 4-nitrophenol Homo sapiens
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + beta-estradiol Mus musculus
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + beta-estradiol Homo sapiens
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + dehydroepiandrosterone Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + dehydroepiandrosterone Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + desipramine Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + desipramine Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + L-triiodothyronine Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + L-triiodothyronine Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + xanthurenic acid Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + xanthurenic acid Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + 1-naphthol Mus musculus
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + 4-nitrophenol Mus musculus
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + beta-estradiol Mus musculus
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + dehydroepiandrosterone Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + desipramine Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + L-triiodothyronine Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + xanthurenic acid Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + 1-naphthol Homo sapiens
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + 4-nitrophenol Homo sapiens
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + beta-estradiol Homo sapiens
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + dehydroepiandrosterone Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + desipramine Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + L-triiodothyronine Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + xanthurenic acid Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + 1-naphthol Homo sapiens
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + 4-nitrophenol Homo sapiens
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + beta-estradiol Homo sapiens
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + dehydroepiandrosterone Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + desipramine Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + L-triiodothyronine Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + xanthurenic acid Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + 1-naphthol Mus musculus
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + 1-naphthol Homo sapiens
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + 4-nitrophenol Mus musculus
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + 4-nitrophenol Homo sapiens
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + beta-estradiol Mus musculus
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + beta-estradiol Homo sapiens
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + dehydroepiandrosterone Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + dehydroepiandrosterone Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + desipramine Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + desipramine Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + L-triiodothyronine Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + L-triiodothyronine Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + xanthurenic acid Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + xanthurenic acid Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens P0DMM9
-
-
2.8.2.1 Homo sapiens P50225
-
-
2.8.2.1 Mus musculus
-
-
-
2.8.2.1 Mus musculus Q9QWG7
-
-
2.8.2.3 Mus musculus
-
-
-
2.8.2.4 Homo sapiens P49888
-
-
2.8.2.14 Homo sapiens Q06520
-
-
2.8.2.15 Homo sapiens
-
-
-
2.8.2.15 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.1 Ni-NTA agarose column chromatography Mus musculus
2.8.2.1 Ni-NTA agarose column chromatography Homo sapiens
2.8.2.3 Ni-NTA agarose column chromatography Mus musculus
2.8.2.4 Ni-NTA agarose column chromatography Homo sapiens
2.8.2.14 Ni-NTA agarose column chromatography Homo sapiens
2.8.2.15 Ni-NTA agarose column chromatography Mus musculus
2.8.2.15 Ni-NTA agarose column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + 1-naphthol
-
Mus musculus adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + 1-naphthol
-
Homo sapiens adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + 4-nitrophenol
-
Mus musculus adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + 4-nitrophenol
-
Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + beta-estradiol
-
Mus musculus adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + beta-estradiol
-
Homo sapiens adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + desipramine
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + desipramine
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + L-triiodothyronine
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + L-triiodothyronine
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + xanthurenic acid
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + xanthurenic acid
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + 1-naphthol
-
Mus musculus adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + 4-nitrophenol
-
Mus musculus adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + beta-estradiol
-
Mus musculus adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + desipramine
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + L-triiodothyronine
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.3 3'-phosphoadenylyl sulfate + xanthurenic acid
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + 1-naphthol
-
Homo sapiens adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + 4-nitrophenol
-
Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + beta-estradiol
-
Homo sapiens adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + desipramine
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + L-triiodothyronine
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.4 3'-phosphoadenylyl sulfate + xanthurenic acid
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + 1-naphthol
-
Homo sapiens adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + 4-nitrophenol
-
Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + beta-estradiol
-
Homo sapiens adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + desipramine
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + L-triiodothyronine
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.14 3'-phosphoadenylyl sulfate + xanthurenic acid
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + 1-naphthol
-
Mus musculus adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + 1-naphthol
-
Homo sapiens adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + 4-nitrophenol
-
Mus musculus adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + 4-nitrophenol
-
Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + beta-estradiol
-
Mus musculus adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + beta-estradiol
-
Homo sapiens adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + desipramine
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + desipramine
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + L-triiodothyronine
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + L-triiodothyronine
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + xanthurenic acid
-
Mus musculus adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.15 3'-phosphoadenylyl sulfate + xanthurenic acid
-
Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 cytosolic sulfotransferase
-
Mus musculus
2.8.2.1 cytosolic sulfotransferase
-
Homo sapiens
2.8.2.1 SULT1A1 isoform Mus musculus
2.8.2.1 SULT1A1 isoform Homo sapiens
2.8.2.1 SULT1A3 isoform Homo sapiens
2.8.2.1 SULT1B1 isoform Mus musculus
2.8.2.3 cytosolic sulfotransferase
-
Mus musculus
2.8.2.3 SULT3A1 isoform Mus musculus
2.8.2.4 cytosolic sulfotransferase
-
Homo sapiens
2.8.2.4 SULT1E1 isoform Homo sapiens
2.8.2.14 cytosolic sulfotransferase
-
Homo sapiens
2.8.2.14 SULT2A1 isoform Homo sapiens
2.8.2.15 cytosolic sulfotransferase
-
Mus musculus
2.8.2.15 cytosolic sulfotransferase
-
Homo sapiens
2.8.2.15 SULT1B1 isoform Homo sapiens
2.8.2.15 SULT1C2 isoform Homo sapiens
2.8.2.15 SULT1D1 isoform Mus musculus
2.8.2.15 SULT2A1 isoform Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.8.2.1 0.00002
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus 2,6-Dichloro-4-nitrophenol
2.8.2.1 0.00017
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens 2,6-Dichloro-4-nitrophenol
2.8.2.1 0.00039
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens 2,6-Dichloro-4-nitrophenol
2.8.2.1 0.0004
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus 2,6-Dichloro-4-nitrophenol
2.8.2.1 0.00072
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus gavestinel
2.8.2.1 0.00092
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus gavestinel
2.8.2.1 0.003
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus Kynurenic acid
2.8.2.1 0.0049
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus Kynurenic acid
2.8.2.1 0.005
-
IC50 above 0.005 mM, isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus Mefenamic acid
2.8.2.1 0.005
-
IC50 above 0.005 mM, isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus Mefenamic acid
2.8.2.1 0.0106
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens gavestinel
2.8.2.1 0.0137
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens 5,7-dichlorokynurenic acid
2.8.2.1 0.0149
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens Mefenamic acid
2.8.2.1 0.018
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus 2,6-Dichloro-4-nitrophenol
2.8.2.1 0.0188
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens Kynurenic acid
2.8.2.1 0.0208
-
IC50 above 1.0 mM, isoform SULT1A1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens 5,7-dichlorokynurenic acid
2.8.2.1 0.022
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens Kynurenic acid
2.8.2.1 0.0304
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens Mefenamic acid
2.8.2.1 0.0372
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus 2,6-Dichloro-4-nitrophenol
2.8.2.1 0.0696
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus 5,7-dichlorokynurenic acid
2.8.2.1 0.0986
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus 5,7-dichlorokynurenic acid
2.8.2.1 0.117
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens L689,560
2.8.2.1 0.1663
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus L689,560
2.8.2.1 0.1796
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus L689,560
2.8.2.1 0.25
-
IC50 above 0.25 mM, isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus Kynurenic acid
2.8.2.1 0.25
-
IC50 above 0.25 mM, isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens L689,560
2.8.2.1 0.25
-
IC50 above 0.25 mM, isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Mus musculus Kynurenic acid
2.8.2.1 146
-
IC50 above 0.25 mM, isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens gavestinel
2.8.2.15 0.0012
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens gavestinel
2.8.2.15 0.0017
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens gavestinel
2.8.2.15 0.005
-
IC50 above 0.005 mM, isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens Mefenamic acid
2.8.2.15 0.005
-
IC50 above 0.005 mM, isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens Mefenamic acid
2.8.2.15 0.0337
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens Kynurenic acid
2.8.2.15 0.0342
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens 2,6-Dichloro-4-nitrophenol
2.8.2.15 0.0473
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens L689,560
2.8.2.15 0.0536
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens L689,560
2.8.2.15 0.1642
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens 5,7-dichlorokynurenic acid
2.8.2.15 0.2536
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens 5,7-dichlorokynurenic acid
2.8.2.15 9
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens Kynurenic acid
2.8.2.15 24
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C Homo sapiens 2,6-Dichloro-4-nitrophenol