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Literature summary extracted from

  • Eom, G.H.; Kim, K.; Kim, S.M.; Kee, H.J.; Kim, J.Y.; Jin, H.M.; Kim, J.R.; Kim, J.H.; Choe, N.; Kim, K.B.; Lee, J.; Kook, H.; Kim, N.; Seo, S.B.
    Histone methyltransferase PRDM8 regulates mouse testis steroidogenesis (2009), Biochem. Biophys. Res. Commun., 388, 131-136.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.355 the 70 kDa full-length form is expressed in HEK-293T cells Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.355 nucleus the full-length of PRDM8 is localized exclusively in the nuclear region Mus musculus 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.355 30000
-
 the 30 kDa PRDM8 is most abundant in testis, heart, liver, and kidney, SDS-PAGE Mus musculus
2.1.1.355 70000
-
 the 70 kDa full-length PRDM8 is most abundant in brain and testis, SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.355 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.355 brain PRDM8 of 70 kDa Mus musculus
-
2.1.1.355 heart PRDM8 of 30 kDa is expressed most prominently in cardiomyocytes from the heart Mus musculus
-
2.1.1.355 kidney PRDM8 of 30 kDa Mus musculus
-
2.1.1.355 liver PRDM8 of 70 kDa and of 30 kDa Mus musculus
-
2.1.1.355 additional information PRDM8 is not expressed in intestinal smooth muscles Mus musculus
-
2.1.1.355 oral epithelium
-
 Mus musculus
-
2.1.1.355 renal tubule
-
 Mus musculus
-
2.1.1.355 testis PRDM8 of 70 kDa Mus musculus
-
2.1.1.355 tongue PRDM8 is expressed most prominently in striated skeletal muscle from the tongue Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.355 S-adenosyl-L-methionine + histone H2A
-
 Mus musculus S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.355 S-adenosyl-L-methionine + histone H2B
-
 Mus musculus S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.355 S-adenosyl-L-methionine + histone H3(K9) PRDM8 specifically methylates H3(K9) of histones Mus musculus S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.355 S-adenosyl-L-methionine + histone H4
-
 Mus musculus S-adenosyl-L-homocysteine + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.355 histone methyltransferase
-
 Mus musculus
2.1.1.355 HMTase
-
 Mus musculus
2.1.1.355 PRDM8
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.1.1.355 Mus musculus the expression of 70 kDa PRDM8 in brain and testis abruptly increases 3 weeks after birth up

General Information

EC Number General Information Comment Organism
2.1.1.355 physiological function PRDM8 repressed the expression of steroidogenic markers, p450c17c and luteinizing hormone receptor, which indicates its regulatory role in mouse testis development and steroidogenesis Mus musculus