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Literature summary extracted from

  • Nishiyama, T.; Ohnuma, T.; Inoue, Y.; Kishi, T.; Ogura, K.; Hiratsuka, A.
    UDP-glucuronosyltransferases 1A6 and 1A10 catalyze reduced menadione glucuronidation (2008), Biochem. Biophys. Res. Commun., 371, 247-250.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 isoform UGT1A10, expression in insect cell Homo sapiens
2.4.1.17 isoform UGT1A6, expression in insect cell Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 jejunum isoform UGT1A10, preferential formation of 4-menadiol glucuronide Homo sapiens
-
2.4.1.17 liver isoform UGT1A10 Homo sapiens
-
2.4.1.17 liver isoform UGT1A6, preferential formation of 1-menadiol glucuronide Homo sapiens
-
2.4.1.17 additional information no activity of isoform UGT1A6 in the jejunum Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 UDP-D-glucuronate + menadiol
-
 Homo sapiens UDP + mendadiol 1-O-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + menadiol
-
 Homo sapiens UDP + mendadiol 1-O-beta-D-glucuronoside isoform UGT1A6, formation of 1-menadiol glucuronide and 4-menadiol glucuronide in ratio of about 4:1 ?
2.4.1.17 UDP-D-glucuronate + menadiol
-
 Homo sapiens UDP + mendadiol 4-O-beta-D-glucuronoside isoform UGT1A10, preferential formation of 4-menadiol glucuronoside ?
2.4.1.17 UDP-D-glucuronate + menadiol
-
 Homo sapiens UDP + mendadiol 4-O-beta-D-glucuronoside isoform UGT1A6, formation of 1-menadiol glucuronide and 4-menadiol glucuronide in ratio of about 4:1 ?