EC Number | Application | Comment | Organism |
---|---|---|---|
5.3.99.4 | medicine | tyrosine nitration of prostacyclin synthase is correlated with an excessive inflammatory response in atherosclerotic carotid arteries from patients with type 2 diabetes | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.4 | Prostaglandin H2 | Homo sapiens | - |
Prostaglandin I2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.3.99.4 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
5.3.99.4 | additional information | diabetes induces prostacyclin synthase nitration in carotid plaques | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
5.3.99.4 | aortic endothelial cell | HAEC | Homo sapiens | - |
5.3.99.4 | carotid artery | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.4 | Prostaglandin H2 | - |
Homo sapiens | Prostaglandin I2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.3.99.4 | PGIS | - |
Homo sapiens |
5.3.99.4 | prostacyclin synthase | - |
Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
5.3.99.4 | Homo sapiens | hyperglycemia and palmitate increase prostacyclin synthase nitration and reduce its activity | down |