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Literature summary extracted from

  • Yuan, Y.; Fuse, S.; Ostash, B.; Sliz, P.; Kahne, D.; Walker, S.
    Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design (2008), ACS Chem. Biol., 3, 429-436.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.129 complex of neryl-moenomycin A bound to the peptidoglycan glycosyltransferase domain of PBP1A Aquifex aeolicus

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.129 E83A mutant with undetectable activity Aquifex aeolicus
2.4.1.129 K124A mutant shows 5fold reduced activity compared to the wild type enzyme Aquifex aeolicus
2.4.1.129 K137A mutant with undetectable activity Aquifex aeolicus
2.4.1.129 Q121A mutant with undetectable activity Aquifex aeolicus
2.4.1.129 R132A mutant with barely detectable activity (about 3% of wild type) Aquifex aeolicus
2.4.1.129 S116A mutant shows 10fold reduced activity compared to the wild type enzyme Aquifex aeolicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.129 moenomycin A active site inhibitor Aquifex aeolicus
2.4.1.129 neryl-moenomycin A active site inhibitor Aquifex aeolicus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.129 Aquifex aeolicus O66874
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.129
-
 Aquifex aeolicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.129 [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 Aquifex aeolicus [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.129 PBP1a
-
 Aquifex aeolicus
2.4.1.129 PGT
-
 Aquifex aeolicus