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Literature summary extracted from

  • Cramm-Behrens, C.I.; Dienst, M.; Jacob, R.
    Apical cargo traverses endosomal compartments on the passage to the cell surface (2008), Traffic, 9, 2206-2220.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.2.1.62 additional information presence of Rab8T22N–CFP results in an increase in LPH–YFP-containing vesicular structures Homo sapiens

Application

EC Number Application Comment Organism
3.2.1.62 additional information regulation of LPH exocytosis by multiple Rab GTPases Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.1.62 COS-1 cells triple transfected with LPH–CFP, SI–YFP and Rab4, Rab8 or Rab11 fused to DsRed. MDCK cells stably expressing LPHmyc Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.62 additional information coexpression with Rab4S22N or Rab11S25N decreases the number of vesicular structures positive for LPH. Trafficking delay of LPH following Rab protein depletion in MDCK cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.62 additional information sequential passage of LPH through Rab4-, Rab8- and Rab11-containing compartments. Trafficking of LPH from the TGN to the cell surface can be modulated by dominant-negative Rab8 Homo sapiens
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3.7.1.4 apical plasma membrane LPH traverses endosomal compartments before entering the apical membrane (fluorescence microscopic and biochemical approach) Canis lupus familiaris 16324
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3.7.1.4 endosome LPH traverses endosomal compartments before entering the apical membrane (fluorescence microscopic and biochemical approach) Canis lupus familiaris 5768
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Organism

EC Number Organism UniProt Comment Textmining
3.2.1.62 Homo sapiens
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-
-
3.7.1.4 Canis lupus familiaris
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.7.1.4 MDCK cell
-
 Canis lupus familiaris
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Synonyms

EC Number Synonyms Comment Organism
3.2.1.62 lactase-phlorizin hydrolase
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 Homo sapiens
3.2.1.62 LPH
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 Homo sapiens
3.7.1.4 lactase-phlorizin hydrolase
-
 Canis lupus familiaris
3.7.1.4 LPH
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 Canis lupus familiaris