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Literature summary extracted from

  • Perez, M.J.; Castano, B.; Jimenez, S.; Serrano, M.A.; Gonzalez-Buitrago, J.M.; Marin, J.J.
    Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy (2008), Toxicol. Appl. Pharmacol., 232, 327-336.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.24 cytoplasm
-
 Rattus norvegicus 5737
-
1.3.1.24 cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.24 bilirubin + NADP+ Rattus norvegicus
-
 biliverdin + NADPH + H+
-
 r
1.3.1.24 bilirubin + NADP+ Homo sapiens
-
 biliverdin + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.24 Homo sapiens P53004
-
-
1.3.1.24 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.24 Hep-G2 cell
-
 Homo sapiens
-
1.3.1.24 JAR cell
-
 Homo sapiens
-
1.3.1.24 liver
-
 Rattus norvegicus
-
1.3.1.24 placenta
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.24 bilirubin + NADP+
-
 Rattus norvegicus biliverdin + NADPH + H+
-
 r
1.3.1.24 bilirubin + NADP+
-
 Homo sapiens biliverdin + NADPH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.3.1.24 biliverdin IXalpha reductase
-
 Rattus norvegicus
1.3.1.24 biliverdin IXalpha reductase
-
 Homo sapiens
1.3.1.24 biliverdin reductase
-
 Rattus norvegicus
1.3.1.24 biliverdin reductase
-
 Homo sapiens
1.3.1.24 BVR
-
 Rattus norvegicus
1.3.1.24 BVR
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.24 NADPH
-
 Rattus norvegicus
1.3.1.24 NADPH
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.3.1.24 Rattus norvegicus in fetal liver and maternal liver and placenta ursodeoxycholic acid up-regulates biliverdin-IX reductase up
1.3.1.24 Homo sapiens in HepG2 and JAr cells taurocholic acid and ursodeoxycholic acid up-regulate biliverdin-IX reductase up