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Literature summary extracted from

  • Stern, R.
    Hyaluronidases in cancer biology (2008), Semin. Cancer Biol., 18, 275-280.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.2.1.35 medicine human cancers grown in SCID mice regress dramatically following administration of purified testicular hyaluronidase. Hyaluronidase treatment also prevents lymph node invasion in a murine model for T-cell lymphoma Homo sapiens
3.2.1.35 medicine hyaluronidase correlates with tumor progression which is documented in tumors of the male genito-urinary tract, in prostate and urinary bladder cancers. Aggressiveness of other human cancers also correlates with hyaluronidase, including breast and laryngeal cancer Homo sapiens
3.2.1.35 medicine hyaluronidases are added to anticancer regimens, particularly in Europe. Tumors previously resistant to chemotherapy become sensitive when hyaluronidase is added. The enzyme may decrease intratumoral pressure, permitting drugs to penetrate the malignancy. Studies are available suggesting that hyaluronidase has intrinsic anti-tumor activity Homo sapiens
3.2.1.35 molecular biology the influence of hyaluronidase digestion modulates CD44 expression in various cancer cell lines Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.35 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.35 hyaluronan + H2O hyaluronan deposition and turnover is even more abundant and more rapid in malignant tissues. The proportion of low molecular weight (LMW) fragments of HA is greater in tumors and tumor patients than in the normal Homo sapiens ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.35 hyaluronidase
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 Homo sapiens