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Literature summary extracted from

  • Hoque, M.; Hanauske-Abel, H.M.; Palumbo, P.; Saxena, D.; DAlliessi Gandolfi, D.; Park, M.H.; Peery, T.; Mathews, M.B.
    Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A (2009), Retrovirology, 6, 90.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.14.99.29 medicine the results support the concept that drugs targeting DOHH should be tested clinically for HIV-1 inhibition and could be developed as antiretrovirals Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.99.29 ciclopirox CPX, topical fungicide Homo sapiens
1.14.99.29 deferiprone DEF, systemic medicinal iron chelator Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.29 additional information Homo sapiens DOHH hydroxylates the deoxyhypusyl-eukaryotic translation initiation factor eIF5A intermediate to hyposine-containing mature eIF5A using molecular oxygen ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.29 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.99.29 PBMC cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.29 additional information DOHH hydroxylates the deoxyhypusyl-eukaryotic translation initiation factor eIF5A intermediate to hyposine-containing mature eIF5A using molecular oxygen Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.29 deoxyhypusine hydroxylase
-
 Homo sapiens
1.14.99.29 DOHH
-
 Homo sapiens