EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.1.138 | plasma membrane | - |
Drosophila melanogaster | 5886 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.138 | ATP + ceramide | Drosophila melanogaster | ceramide is an important regulator of photoreceptor viability | ADP + ceramide 1-phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.138 | Drosophila melanogaster | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.138 | ATP + ceramide | ceramide is an important regulator of photoreceptor viability | Drosophila melanogaster | ADP + ceramide 1-phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.138 | ceramide kinase | - |
Drosophila melanogaster |
2.7.1.138 | CERK | - |
Drosophila melanogaster |
2.7.1.138 | DCERK protein | - |
Drosophila melanogaster |
EC Number | Organism | Comment | Expression |
---|---|---|---|
2.7.1.138 | Drosophila melanogaster | DCERK protein is expressed during all developmental stages | additional information |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.138 | malfunction | a mutation in ceramide kinase specifically leads to proteolysis of NORPA, consequent loss of phosphoinositide-specific phospholipase C activity, and failure in light signal transduction, a significant increase in ceramide, resulting from lack of ceramide kinase, perturbs the membrane microenvironment of phosphatidylinositol-4,5-bisphosphate, altering its distribution | Drosophila melanogaster |
2.7.1.138 | physiological function | ceramide kinase, is a novel regulator of phosphoinositide-specific phospholipase C signaling and photoreceptor homeostasis, DCERK has a diacylglycerol kinase domain and a Ca2+/calmodulin binding domain | Drosophila melanogaster |