Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Jia, Y.; Loison, F.; Hattori, H.; Li, Y.; Erneux, C.; Park, S.Y.; Gao, C.; Chai, L.; Silberstein, L.E.; Schurmans, S.; Luo, H.R.
    Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis (2008), Proc. Natl. Acad. Sci. USA, 105, 4739-4744.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.127 generation of knock-out mice Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Mus musculus
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 central nervous system
-
 Mus musculus
-
2.7.1.127 hematopoietic stem cell inositol trisphosphate 3-kinase B gene is expressed in all hematopoietic stem/progenitor cell populations Mus musculus
-
2.7.1.127 testis
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Mus musculus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.127 inositol trisphosphate 3-kinase B
-
 Mus musculus
2.7.1.127 InsP3KB
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.1.127 malfunction disruption of InsP3KB leads to impaired T cell and B cell development as well as hyperactivation of neutrophils, in InsP3KB null mice, the bone marrow granulocyte monocyte progenitor (GMP) population is expanded, and GMP cells proliferated significantly faster, neutrophil production in the bone marrow is enhanced, and the peripheral blood neutrophil count is also substantially elevated, neutrophil apoptotic death is enhanced in enzyme knock-out mice, disruption of enzyme promotes myeloid differentiation Mus musculus
2.7.1.127 physiological function physiological modulator of myelopoiesis, enzyme plays a crucial role in hematopoiesis Mus musculus